SLA2 and CD247

Number of citations of the paper that reports this interaction (PMID 11891219)
6

Data Source:
HPRD (in vivo)

		SLA2	CD247
Gene Name		Src-like-adaptor 2	CD247 molecule
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Late Endosome Plasma Membrane Endosome Membrane Cytoplasmic Membrane-bounded Vesicle	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein N-terminus Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Signal Transduction B Cell Mediated Immunity Intracellular Receptor Signaling Pathway T Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of B Cell Activation	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		6 interactors: CBL CD247 CSF1 ERBB2 LAMC2 ZAP70	38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		84174	919
HPRD ID		05955	01729
Ensembl ID		ENSG00000101082	ENSG00000198821
Uniprot IDs		Q9H6Q3	P20963
PDB IDs			1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Mammary Gland Fat Development T Cell Receptor Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Beta Selection Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Proliferation Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Osteoclast Proliferation Positive Regulation Of Cell Proliferation Immune System Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Immature T Cell Proliferation In Thymus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Monocyte Differentiation Mammary Duct Terminal End Bud Growth Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Growth Positive Regulation Of Cell-cell Adhesion Monocyte Activation Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Activation	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		adjacent already bases blh1 cerevisiae correspond cosmid displays dnaj finger frames globin interesting kex2 motifs n1254 nii42 orf orfs reading remaining saccharomyces sequenced similarity sin4 ure2 xiv zinc zwf1	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Difference) ?		adjacent bases blh1 cerevisiae correspond cosmid displays dnaj finger frames globin interesting kex2 motifs n1254 nii42 orf orfs reading remaining saccharomyces sequenced similarity sin4 ure2 xiv zinc zwf1	annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Intersection) ?		already