SLA2 and EPHA4

Number of citations of the paper that reports this interaction (PubMedID 33617900)
0

Data Source:
BioGRID (enzymatic study)

		SLA2	EPHA4
Description		Src like adaptor 2	EPH receptor A4
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Late Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle	Cytoplasm Mitochondrial Outer Membrane Endosome Early Endosome Plasma Membrane Adherens Junction Cell Surface Postsynaptic Density Membrane Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Presynaptic Membrane Cell Projection Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Axonal Growth Cone Cell Body Synapse Postsynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Signaling Adaptor Activity	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Mediated Immunity T Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cell Adhesion Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Glial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Negative Regulation Of Translation Corticospinal Tract Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Adherens Junction Organization Regulation Of GTPase Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Translational Initiation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Innervation Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Cochlea Development Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Neuron Projection Guidance Synapse Pruning Neuron Projection Fasciculation Membraneless Organelle Assembly Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Modification Of Synaptic Structure Regulation Of Synapse Pruning
Pathways		Negative regulation of FLT3	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells Somitogenesis
Drugs			Fostamatinib
Diseases
GWAS			Adolescent idiopathic scoliosis ( 26394188) Blond vs. brown/black hair color ( 30531825) Brain imaging ( 20100581) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cortical surface area (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Entorhinal cortical volume ( 31530798) Face memory ( 31596458) Hair color ( 29662168) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Nose size ( 27182965) Paclitaxel-induced neuropathy ( 23776197) Rostral anterior cingulate cortex volume ( 31530798) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels in lean individuals ( 25811787)
Interacting Genes		16 interacting genes: CBL CD247 CSF1 EGFR EPHA4 ERBB2 ERBB3 ERBB4 GAB1 KIT LAMC2 MAP1LC3A MET PRKAA2 UBASH3A ZAP70	19 interacting genes: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 ERBB2 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF RNF5 SLA2 SRC TNS3
Entrez ID		84174	2043
HPRD ID		05955	03719
Ensembl ID		ENSG00000101082	ENSG00000116106
Uniprot IDs		Q9H6Q3	E9PG71 P54764
PDB IDs		4M4Z	2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2 7OFV 9CY8
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB2 Signaling Pathway Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Signal Transduction Receptor Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Transferase Activity Positive Regulation Of Locomotion ERBB3:ERBB2 Complex Regulation Of Cell Migration ATP Binding Regulation Of MAPK Cascade Regulation Of Cell Motility Regulation Of Programmed Cell Death Regulation Of Locomotion Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Nucleotide Binding Protein Tyrosine Kinase Binding Cell Migration Intracellular Signal Transduction Positive Regulation Of Phosphate Metabolic Process ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Activity Regulation Of Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation Neuron Projection Guidance Axon Guidance Protein Tyrosine Kinase Activity Neuron Projection Development Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Binding Regulation Of Developmental Process Positive Regulation Of Lipase Activity Cell Projection Organization Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Phosphorylation T Cell Costimulation Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Phosphorylation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Neuron Projection Development Signal Transduction Regulation Of Cell Projection Organization Regulation Of Postsynapse Organization Positive Regulation Of MAPK Cascade Transmembrane-ephrin Receptor Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Protein Kinase Activity Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Cell Adhesion Negative Regulation Of Cell Projection Organization Cell Differentiation Protein Phosphorylation
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