SLA2 and LAMC2

Number of citations: 0 (PubMedID 17353186)
Data Source: BioGRID (far western blotting)

		SLA2	LAMC2
Name		Src like adaptor 2	laminin subunit gamma 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Late Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Extracellular Matrix Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Signaling Adaptor Activity	Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Mediated Immunity T Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway	Cell Adhesion Positive Regulation Of Cell Population Proliferation Epidermis Development Positive Regulation Of Cell Migration
Pathways		Negative regulation of FLT3	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Diseases		None	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		No GWAS studies recorded	Acne (severe) ( 30542056 ) Blood protein levels ( 30072576 ) Clozapine-induced agranulocytosis ( 25187353 ) HDL cholesterol ( 21347282 ) Low density lipoprotein cholesterol levels ( 32154731 ) Morning person ( 30696823 ) Systemic lupus erythematosus ( 21408207 )
Novel Interactors		None recorded	1 novel interactors: SCAP
Interacting Genes		16 interacting genes: CBL CD247 CSF1 EGFR EPHA4 ERBB2 ERBB3 ERBB4 GAB1 KIT LAMC2 MAP1LC3A MET PRKAA2 UBASH3A ZAP70	7 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SLA2
Entrez ID		84174	3918
HPRD ID		05955	01031
Ensembl ID		ENSG00000101082	ENSG00000058085
Uniprot IDs		Q9H6Q3	Q13753
PDB IDs		4M4Z	Not available
GO Terms Enriched among Interactors		Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB2 Signaling Pathway Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Signal Transduction Receptor Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Transferase Activity Positive Regulation Of Locomotion ERBB3:ERBB2 Complex Regulation Of Cell Migration ATP Binding Regulation Of MAPK Cascade Regulation Of Cell Motility Regulation Of Programmed Cell Death Regulation Of Locomotion Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Nucleotide Binding Protein Tyrosine Kinase Binding Cell Migration Intracellular Signal Transduction Positive Regulation Of Phosphate Metabolic Process ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding	Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Binding Endodermal Cell Differentiation Collagen Type VII Trimer SREBP-SCAP Complex CSF1-CSF1R Complex Macrophage Colony-stimulating Factor Receptor Activity Response To Vitamin B3 Extracellular Region