SLA2 and LAMC2

Number of citations of the paper that reports this interaction (PMID 17353186)
4

Data Source:
BioGRID (far western blotting)

		SLA2	LAMC2
Gene Name		Src-like-adaptor 2	laminin, gamma 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Late Endosome Plasma Membrane Endosome Membrane Cytoplasmic Membrane-bounded Vesicle	Extracellular Region Laminin-2 Complex Laminin-5 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein N-terminus Binding	Heparin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Signal Transduction B Cell Mediated Immunity Intracellular Receptor Signaling Pathway T Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of B Cell Activation	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly
Pathways			Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS			Coronary heart disease ( 21347282) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		6 interactors: CBL CD247 CSF1 ERBB2 LAMC2 ZAP70	6 interactors: BMP1 COL7A1 FBLN2 LAMB3 NID1 SLA2
Entrez ID		84174	3918
HPRD ID		05955	01031
Ensembl ID		ENSG00000101082	ENSG00000058085
Uniprot IDs		Q9H6Q3	Q13753
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Mammary Gland Fat Development T Cell Receptor Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Beta Selection Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Proliferation Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Osteoclast Proliferation Positive Regulation Of Cell Proliferation Immune System Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Immature T Cell Proliferation In Thymus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Monocyte Differentiation Mammary Duct Terminal End Bud Growth Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Growth Positive Regulation Of Cell-cell Adhesion Monocyte Activation Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Activation	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Cell Adhesion Endoderm Development Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Gastrulation Regulation Of Cell-substrate Adhesion Epidermis Development Negative Regulation Of Calcium-mediated Signaling Hemidesmosome Assembly Positive Regulation Of Cell Adhesion Glomerular Basement Membrane Development Basement Membrane Organization Cartilage Condensation Tissue Development
Tagcloud ?		adjacent already bases blh1 cerevisiae correspond cosmid displays dnaj finger frames globin interesting kex2 motifs n1254 nii42 orf orfs reading remaining saccharomyces sequenced similarity sin4 ure2 xiv zinc zwf1	accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis
Tagcloud (Difference) ?		adjacent already bases blh1 cerevisiae correspond cosmid displays dnaj finger frames globin interesting kex2 motifs n1254 nii42 orf orfs reading remaining saccharomyces sequenced similarity sin4 ure2 xiv zinc zwf1	accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis
Tagcloud (Intersection) ?