TPH1

Gene Name		tryptophan hydroxylase 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Neuron Projection
	Molecular Function	Tryptophan 5-monooxygenase Activity Iron Ion Binding Amino Acid Binding
	Biological Process	Circadian Rhythm Aromatic Amino Acid Family Metabolic Process Negative Regulation Of Ossification Cellular Nitrogen Compound Metabolic Process Response To Immobilization Stress Serotonin Biosynthetic Process Small Molecule Metabolic Process Positive Regulation Of Fat Cell Differentiation Indolalkylamine Biosynthetic Process Bone Remodeling Oxidation-reduction Process Mammary Gland Alveolus Development
Pathways		Amine-derived hormones Serotonin and melatonin biosynthesis Metabolism of amino acids and derivatives
Drugs		Tetrahydrobiopterin 7,8-Dihydro-L-Biopterin
Diseases
GWAS
Protein-protein Interactions		4 interactors: APP PRKACA YWHAH YWHAZ
Entrez ID		7166
HPRD ID		01846
Ensembl ID
Uniprot IDs		P17752
PDB IDs		1IN9 1MLW 3HF6 3HF8 3HFB
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Platelet Activation Apoptotic Process Programmed Cell Death Positive Regulation Of Intracellular Transport Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Blood Coagulation Hemostasis Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Regulation Of Body Fluid Levels Wound Healing Regulation Of Establishment Of Protein Localization Cell Activation Regulation Of Mitochondrion Organization Response To Wounding Positive Regulation Of Transport Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Glucocorticoid Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Membrane Organization Regulation Of Signal Transduction Regulation Of Ion Transmembrane Transporter Activity Regulation Of Protein Binding Regulation Of Transmembrane Transporter Activity Cell Maturation Regulation Of Signaling Synaptic Growth At Neuromuscular Junction Histone H3-T6 Phosphorylation Regulation Of Cellular Localization Negative Regulation Of Neuron Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Collateral Sprouting In Absence Of Injury Positive Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction Lipid Metabolic Process Immune Response Golgi Reassembly Lipid Catabolic Process Steroid Metabolic Process Defense Response Regulation Of Binding
Tagcloud ?		acaca crh deregressed dgat1 fasn fertility fp fy gh1 holstein lep lgb longevity mastitis mfge8 milk mscc paep pft piebaldism positives pp ppargc1a proofs py relatedness sires thrsp traits