TPH1 and PSTPIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TPH1	PSTPIP1
Description		tryptophan hydroxylase 1	proline-serine-threonine phosphatase interacting protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Neuron Projection	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Monooxygenase Activity Tryptophan 5-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Platelet Degranulation Serotonin Biosynthetic Process From Tryptophan Aromatic Amino Acid Metabolic Process Serotonin Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Bone Remodeling Mammary Gland Alveolus Development Regulation Of Hemostasis	Immune System Process Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response
Pathways		Serotonin and melatonin biosynthesis NGF-stimulated transcription	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs		Sapropterin LX1031 Telotristat ethyl
Diseases			Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Glucose homeostasis traits ( 30576415) HDL cholesterol ( 30275531) White blood cell count ( 32888494)	Hip circumference adjusted for BMI ( 34021172) Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: APP GORASP2 PRKACA PSTPIP1 YWHAH YWHAZ	64 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688
Entrez ID		7166	9051
HPRD ID		01846	05891
Ensembl ID		ENSG00000129167	ENSG00000140368
Uniprot IDs		P17752	A0A0S2Z5P3 J3KPG6 O43586
PDB IDs		1MLW 3HF6 3HF8 3HFB 5J6D 5L01 5TPG 7ZIF 7ZIG 7ZIH 7ZII 7ZIJ 7ZIK 8CJI 8CJJ 8CJK 8CJL 8CJM 8CJN 8CJO	2DIL 7AAL 7AAM 7AAN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Metal Ion Transport TOR Signaling Protein Domain Specific Binding Negative Regulation Of TORC1 Signaling TORC1 Signaling Glucocorticoid Catabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of Calcium-mediated Signaling Establishment Of Protein Localization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Response To Stress Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Establishment Of Localization In Cell Tube Formation Glutamatergic Synapse Transmembrane Transporter Binding Cerebellar Granule Cell To Purkinje Cell Synapse Synaptic Target Recognition Golgi Organization Regulation Of Calcium Ion Transmembrane Transport	Actin Filament Polymerization Protein Polymerization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Actin Polymerization Or Depolymerization SH3 Domain Binding Negative Regulation Of Membrane Tubulation Protein Binding Regulation Of Plasma Membrane Organization MRNA Processing RNA Splicing MRNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Spliceosomal Tri-snRNP Complex Regulation Of Double-strand Break Repair Regulation Of DNA Repair Negative Regulation Of ERBB Signaling Pathway Lamellipodium Morphogenesis Negative Regulation Of Cellular Component Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Podosome Regulation Of Vitamin D Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Spliceosomal Complex Actin Cytoskeleton Ruffle SCAR Complex
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