TPH1 and GORASP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TPH1	GORASP2
Description		tryptophan hydroxylase 1	golgi reassembly stacking protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Neuron Projection	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane
	Molecular Function	Monooxygenase Activity Tryptophan 5-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Metal Ion Binding	Protein Binding
	Biological Process	Platelet Degranulation Serotonin Biosynthetic Process From Tryptophan Aromatic Amino Acid Metabolic Process Serotonin Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Bone Remodeling Mammary Gland Alveolus Development Regulation Of Hemostasis	Response To Unfolded Protein Organelle Organization Golgi Organization Spermatogenesis Cell Differentiation Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Plasma Membrane Organelle Assembly
Pathways		Serotonin and melatonin biosynthesis NGF-stimulated transcription	Golgi Cisternae Pericentriolar Stack Reorganization
Drugs		Sapropterin LX1031 Telotristat ethyl
Diseases
GWAS		Glucose homeostasis traits ( 30576415) HDL cholesterol ( 30275531) White blood cell count ( 32888494)	Autism spectrum disorder ( 34069769) Cognitive performance ( 19734545)
Interacting Genes		6 interacting genes: APP GORASP2 PRKACA PSTPIP1 YWHAH YWHAZ	144 interacting genes: - AAMDC ACY3 ALKBH4 APIP APP ARHGEF15 ARL6IP1 ASMTL ATP6V1G1 ATXN1L BEND5 BLZF1 BTBD3 C1orf94 C21orf91 CARHSP1 CBLB CBY1 CCDC90B CDA CDC23 CDK18 CDKN2D CEP76 CGGBP1 CHMP1A CNTNAP2 CRYAA CRYAB DCTD DMC1 DNAJB13 DPYSL2 DRC12 DUSP21 DUSP4 DYRK3 ECHDC1 EIF2B1 EMILIN3 ENOX1 ENOX2 ETHE1 FIG4 GABPB2 GNG7 GNGT1 GOLGA2 GOLGA6L2 GRIK1 GSTZ1 GTF2IRD1 HOXC5 HSBP1 IFT25 JADE2 KCTD13 KCTD5 KCTD7 KCTD9 KIFC3 KRTAP5-11 LONRF1 LTBP3 MAP1LC3B MAPK1 MAPK14 MAPK8 MATN4 MID2 MIEN1 MIF MORN2 MPLKIP MSC MYOM3 NCOA5 NHSL2 NME1 NMNAT1 NQO2 NUDT5 NUP62 ODC1 OGT PCBD1 PDE9A PNMA5 PRDX3 PRKAB2 PRPS1 PRRC2A PSMA3 PSMD6 RAB1A RAB27B RAB2A RAB39A RAD54B RBM46 REEP6 RGL2 RGS3 RPIA RPS6KA1 SCAND1 SELENBP1 SEPTIN1 SEPTIN14 SHMT1 STOX1 TAGLN TCF4 TEKT3 TGFA TLE5 TMED2 TMED3 TP53RK TPH1 TRAF1 TRAF2 TRAF4 TRAF5 TRAPPC6A TRIM38 TRPT1 TSC22D1 TSC22D4 TSEN15 TSN TTC19 TXLNA UBE2Z UBL3 VPS37B VPS52 XPNPEP1 ZBED1 ZBTB14 ZMAT1 ZMYND19 ZNF148
Entrez ID		7166	26003
HPRD ID		01846	08303
Ensembl ID		ENSG00000129167	ENSG00000115806
Uniprot IDs		P17752	Q9H8Y8
PDB IDs		1MLW 3HF6 3HF8 3HFB 5J6D 5L01 5TPG 7ZIF 7ZIG 7ZIH 7ZII 7ZIJ 7ZIK 8CJI 8CJJ 8CJK 8CJL 8CJM 8CJN 8CJO	3RLE 4EDJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Metal Ion Transport TOR Signaling Protein Domain Specific Binding Negative Regulation Of TORC1 Signaling TORC1 Signaling Glucocorticoid Catabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of Calcium-mediated Signaling Establishment Of Protein Localization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Response To Stress Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Establishment Of Localization In Cell Tube Formation Glutamatergic Synapse Transmembrane Transporter Binding Cerebellar Granule Cell To Purkinje Cell Synapse Synaptic Target Recognition Golgi Organization Regulation Of Calcium Ion Transmembrane Transport	Identical Protein Binding Protein Binding Cytosol Thioesterase Binding Pyrimidine-containing Compound Metabolic Process Protein Homooligomerization Cytoplasm Pyrimidine Nucleotide Biosynthetic Process Protein Complex Oligomerization Pyrimidine-containing Compound Biosynthetic Process Stress-activated MAPK Cascade Protein-containing Complex Organization Pyrimidine Nucleotide Metabolic Process Stress-activated Protein Kinase Signaling Cascade Cytosine Metabolic Process Golgi Organization Ultradian Rhythm Regulation Of Programmed Cell Death Protein-containing Complex Assembly Tumor Necrosis Factor Receptor Binding PTB Domain Binding Negative Regulation Of Programmed Cell Death D-ribose Metabolic Process MAP Kinase Activity Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process ATP Generation From Poly-ADP-D-ribose Nucleoside Monophosphate Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?