REM1 and CACNB4

Number of citations of the paper that reports this interaction (PMID 14623965)
41

Data Source:
HPRD (in vivo)

		REM1	CACNB4
Gene Name		RAS (RAD and GEM)-like GTP-binding 1	calcium channel, voltage-dependent, beta 4 subunit
Image
Gene Ontology Annotations	Cellular Component	Membrane	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse
	Molecular Function	Calmodulin Binding GTP Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Protein Kinase Binding
	Biological Process	Small GTPase Mediated Signal Transduction	Transport Cellular Calcium Ion Homeostasis Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Axon Guidance Neuromuscular Junction Development Adult Walking Behavior Gamma-aminobutyric Acid Secretion Neuronal Action Potential Propagation Synaptic Transmission, Glutamatergic CAMP Metabolic Process Spleen Development Thymus Development Peyer's Patch Development Muscle Fiber Development T Cell Receptor Signaling Pathway Detection Of Light Stimulus Involved In Visual Perception Membrane Depolarization Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways			NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CACNB1 CACNB2 CACNB4 YWHAE YWHAH YWHAQ YWHAZ	9 interactors: CACNA1A CBX3 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3
Entrez ID		28954	785
HPRD ID		15237	09057
Ensembl ID		ENSG00000088320	ENSG00000182389
Uniprot IDs		O75628	E7DBM8 O00305
PDB IDs		2NZJ	1VYV 2D46
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Ion Transmembrane Transport Substantia Nigra Development Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Ion Transport Positive Regulation Of Intracellular Transport Neuromuscular Junction Development Neural Nucleus Development Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Transport Regulation Of Cation Channel Activity Membrane Organization Apoptotic Signaling Pathway Midbrain Development Intracellular Protein Transport Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Intracellular Transport Nervous System Development Cellular Protein Localization Synapse Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Transport Positive Regulation Of Cell Death Establishment Of Protein Localization Regulation Of Calcium Ion Transport Transport Intracellular Transport Regulation Of Establishment Of Protein Localization Calcium Ion Transmembrane Transport Generation Of Neurons Neurogenesis Regulation Of Protein Localization Ion Transport Signaling Regulation Of Membrane Potential Cell Communication Protein Localization Cell-cell Signaling Calcium Ion Transport	Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Chloride Ion Homeostasis Anion Homeostasis Regulation Of Calcium Ion-dependent Exocytosis Acid Secretion Cerebellar Molecular Layer Development Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotransmitter Secretion Vestibular Nucleus Development Cerebellum Maturation G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Musculoskeletal Movement, Spinal Reflex Action Endosomal Lumen Acidification Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Retinal Cell Programmed Cell Death Gamma-aminobutyric Acid Secretion Amino Acid Transport Neurotransmitter Transport Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Necroptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Inflammatory Cell Apoptotic Process Gamma-aminobutyric Acid Transport Regulation Of Neuron Apoptotic Process Cell-cell Signaling Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Hormone Biosynthetic Process Detection Of Calcium Ion Pons Development Regulation Of Neuron Death Positive Regulation Of Calcium Ion-dependent Exocytosis Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Cerebellar Purkinje Cell Differentiation Exocytosis T Cell Apoptotic Process Cerebellar Purkinje Cell Layer Morphogenesis Positive Regulation Of Vesicle Fusion Signaling Neurological System Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction Cell Communication Regulation Of Vesicle-mediated Transport Reflex PH Reduction
Tagcloud ?			altering concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a ppp2r5 ppp2r5d prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Difference) ?			altering concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a ppp2r5 ppp2r5d prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Intersection) ?