REM1 and CACNB4

Number of citations of the paper that reports this interaction (PubMedID 14623965)
32

Data Source:
HPRD (in vivo)

		REM1	CACNB4
Description		RRAD and GEM like GTPase 1	calcium voltage-gated channel auxiliary subunit beta 4
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GO Annotations	Cellular Component	Plasma Membrane T-tubule I Band	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Nuclear Speck Monoatomic Ion Channel Complex Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Calcium Channel Regulator Activity Calmodulin Binding GTP Binding Transmembrane Transporter Binding	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Monoatomic Ion Transport Calcium Ion Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuromuscular Junction Development Adult Walking Behavior Negative Regulation Of Cell Population Proliferation Gamma-aminobutyric Acid Secretion Neuronal Action Potential Propagation Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential CAMP Metabolic Process Spleen Development Thymus Development Peyer's Patch Development T Cell Receptor Signaling Pathway Nervous System Process Detection Of Light Stimulus Involved In Visual Perception Muscle Cell Development Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Protein Localization To Nucleolus Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways			Presynaptic depolarization and calcium channel opening NCAM1 interactions
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Nicardipine Magnesium sulfate Verapamil Levomenthol Nitrendipine Miconazole Amiodarone Mibefradil Dronedarone Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS			Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		7 interacting genes: CACNB1 CACNB2 CACNB4 YWHAE YWHAH YWHAQ YWHAZ	13 interacting genes: CACNA1A CBX3 CCDC102B CTBP2 EFHC2 FASLG MAP1A MED31 PTN REM1 SNCA SYT1 TBL3
Entrez ID		28954	785
HPRD ID		15237	09057
Ensembl ID		ENSG00000088320	ENSG00000182389
Uniprot IDs		O75628	A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 E7DBM8 H0Y476 O00305
PDB IDs		2NZJ	2D46
Enriched GO Terms of Interacting Partners?		Voltage-gated Calcium Channel Complex Voltage-gated Calcium Channel Activity Regulation Of Monoatomic Ion Transport Transmembrane Transporter Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Substantia Nigra Development Calcium Channel Regulator Activity Protein Domain Specific Binding Regulation Of Cytosolic Calcium Ion Concentration Neural Nucleus Development Phosphoserine Residue Binding Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Transport Calcium Channel Activity Regulation Of Metal Ion Transport L-type Voltage-gated Calcium Channel Complex High Voltage-gated Calcium Channel Activity Monoatomic Ion Channel Complex Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Intracellular Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Protein Targeting Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Presynapse Calcium Ion Transport Neuromuscular Junction Development Regulation Of Heart Rate By Cardiac Conduction Regulation Of Monoatomic Cation Transmembrane Transport Protein Sequestering Activity Cardiac Conduction Positive Regulation Of Muscle Contraction Chemical Synaptic Transmission Intracellular Protein Localization Membrane Depolarization Trans-synaptic Signaling Synapse Synaptic Signaling Neuron Cellular Homeostasis Negative Regulation Of Monoatomic Ion Transmembrane Transport Glucocorticoid Catabolic Process Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Focal Adhesion Protein Phosphatase Binding	Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Vesicle Fusion Regulation Of Dopamine Secretion Syntaxin Binding Synapse Transcription Coregulator Binding Regulation Of Synaptic Plasticity Dendrite Development Tau Protein Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Vesicle Fusion Positive Regulation Of SNARE Complex Assembly Regulation Of Catecholamine Secretion Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Secretion Synaptic Vesicle Exocytosis Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Cell-cell Signaling Signaling Cell Communication Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Chemical Synaptic Transmission Retrograde Axonal Protein Transport Primary Dendrite Dendrite Regeneration SNARE Binding Regulation Of Norepinephrine Uptake Regulation Of Amine Transport Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Syntaxin-3 Binding Calcium Ion Transmembrane Import Into Cytosol Retinal Cell Programmed Cell Death Trans-synaptic Signaling Synaptic Signaling Neuronal Cell Body Dendritic Branch Dendritic Microtubule Ossification Involved In Bone Remodeling Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Transporter Regulator Activity Regulation Of Neurotransmitter Secretion Vesicle-mediated Transport In Synapse Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
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