REM1 and CACNB2

Number of citations of the paper that reports this interaction (PMID 14623965)
41

Data Source:
HPRD (in vivo)

		REM1	CACNB2
Gene Name		RAS (RAD and GEM)-like GTP-binding 1	calcium channel, voltage-dependent, beta 2 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Sarcolemma
	Molecular Function	Calmodulin Binding GTP Binding	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Small GTPase Mediated Signal Transduction	Transport Synaptic Transmission Axon Guidance Neuromuscular Junction Development Visual Perception Positive Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways			NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses Adrenaline,noradrenaline inhibits insulin secretion
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21909110) Diastolic blood pressure ( 19430479 21909115) Hypertension ( 19430479 21909115) Metabolite levels (HVA/MHPG ratio) ( 23319000) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Protein quantitative trait loci ( 18464913) Quantitative traits ( 19197348) Systolic blood pressure ( 19430479 21909115)
Protein-Protein Interactions		7 interactors: CACNB1 CACNB2 CACNB4 YWHAE YWHAH YWHAQ YWHAZ	2 interactors: PRKACA REM1
Entrez ID		28954	783
HPRD ID		15237	02473
Ensembl ID		ENSG00000088320	ENSG00000165995
Uniprot IDs		O75628	A6PVM6 Q08289 Q59H42 Q5QJ99 Q5VVH1 Q6TME3
PDB IDs		2NZJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Ion Transmembrane Transport Substantia Nigra Development Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Ion Transport Positive Regulation Of Intracellular Transport Neuromuscular Junction Development Neural Nucleus Development Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Transport Regulation Of Cation Channel Activity Membrane Organization Apoptotic Signaling Pathway Midbrain Development Intracellular Protein Transport Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Intracellular Transport Nervous System Development Cellular Protein Localization Synapse Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Transport Positive Regulation Of Cell Death Establishment Of Protein Localization Regulation Of Calcium Ion Transport Transport Intracellular Transport Regulation Of Establishment Of Protein Localization Calcium Ion Transmembrane Transport Generation Of Neurons Neurogenesis Regulation Of Protein Localization Ion Transport Signaling Regulation Of Membrane Potential Cell Communication Protein Localization Cell-cell Signaling Calcium Ion Transport	Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus Cell Communication By Electrical Coupling Activation Of Protein Kinase A Activity Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Sperm Capacitation Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Triglyceride Catabolic Process Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Acylglycerol Catabolic Process Cellular Response To Catecholamine Stimulus Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of CAMP Biosynthetic Process Renal Water Homeostasis Activation Of Adenylate Cyclase Activity Negative Regulation Of Embryonic Development Regulation Of Cardiac Muscle Hypertrophy Regulation Of Protein Export From Nucleus Rhodopsin Mediated Signaling Pathway Regulation Of Platelet Activation Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Negative Regulation Of Smoothened Signaling Pathway
Tagcloud ?			aggregated aggregately ancestry atp2b1 bp conditioning consortium cyp17a1 dbp epidemiology gwas harbor individually intronic jag1 ld maf plekha7 pp rs11191416 rs112467382 rs12806040 rs1571787 rs6163 rs743572 sbp sh2b3 snp strongest
Tagcloud (Difference) ?			aggregated aggregately ancestry atp2b1 bp conditioning consortium cyp17a1 dbp epidemiology gwas harbor individually intronic jag1 ld maf plekha7 pp rs11191416 rs112467382 rs12806040 rs1571787 rs6163 rs743572 sbp sh2b3 snp strongest
Tagcloud (Intersection) ?