REM1 and CACNB1

Number of citations of the paper that reports this interaction (PMID 14623965)
41

Data Source:
HPRD (in vivo)

		REM1	CACNB1
Gene Name		RAS (RAD and GEM)-like GTP-binding 1	calcium channel, voltage-dependent, beta 1 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Voltage-gated Calcium Channel Complex Sarcoplasmic Reticulum T-tubule
	Molecular Function	Calmodulin Binding GTP Binding	Voltage-gated Calcium Channel Activity High Voltage-gated Calcium Channel Activity
	Biological Process	Small GTPase Mediated Signal Transduction	Protein Targeting To Membrane Transport Synaptic Transmission Axon Guidance Neuromuscular Junction Development Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways			NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs			Ibutilide Nimodipine Magnesium Sulfate Verapamil Mibefradil Dronedarone
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CACNB1 CACNB2 CACNB4 YWHAE YWHAH YWHAQ YWHAZ	7 interactors: APP ATN1 CACNA1A DYNLL1 NEDD4L REM1 SRPK1
Entrez ID		28954	782
HPRD ID		15237	11743
Ensembl ID		ENSG00000088320	ENSG00000067191
Uniprot IDs		O75628	Q02641
PDB IDs		2NZJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Ion Transmembrane Transport Substantia Nigra Development Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Ion Transport Positive Regulation Of Intracellular Transport Neuromuscular Junction Development Neural Nucleus Development Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Transport Regulation Of Cation Channel Activity Membrane Organization Apoptotic Signaling Pathway Midbrain Development Intracellular Protein Transport Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Intracellular Transport Nervous System Development Cellular Protein Localization Synapse Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Transport Positive Regulation Of Cell Death Establishment Of Protein Localization Regulation Of Calcium Ion Transport Transport Intracellular Transport Regulation Of Establishment Of Protein Localization Calcium Ion Transmembrane Transport Generation Of Neurons Neurogenesis Regulation Of Protein Localization Ion Transport Signaling Regulation Of Membrane Potential Cell Communication Protein Localization Cell-cell Signaling Calcium Ion Transport	Central Nervous System Development Negative Regulation Of Cellular Metabolic Process Neural Nucleus Development Neuron Apoptotic Process Cell Death Death Neuron Death Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Neuromuscular Process Controlling Balance Cellular Ion Homeostasis Synapse Assembly Metal Ion Homeostasis Action Potential Cerebellar Molecular Layer Development Cellular Chemical Homeostasis Viral Process Ion Homeostasis Adult Locomotory Behavior Vestibular Nucleus Development Positive Regulation Of Caveolin-mediated Endocytosis Synaptic Growth At Neuromuscular Junction Neuromuscular Process Signal Transduction Dendrite Development RNA Metabolic Process Cellular Homeostasis Cell Growth Collateral Sprouting In Absence Of Injury Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Nitrogen Compound Metabolic Process Signaling Adult Behavior Gene Expression Synapse Organization Brain Development Gamma-aminobutyric Acid Secretion Cell Communication Regulation Of Protein Localization Sexual Reproduction Head Development Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Acetylcholine Secretion, Neurotransmission Chemical Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Rhythmic Synaptic Transmission Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
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