WDR77 and PRKG2

Number of citations of the paper that reports this interaction (PubMedID 23755100)
73

Data Source:
BioGRID (pull down)

		WDR77	PRKG2
Description		WD repeat domain 77	protein kinase cGMP-dependent 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cul4B-RING E3 Ubiquitin Ligase Complex Methylosome Transferase Complex	Cytosol Plasma Membrane Membrane Apical Plasma Membrane Nuclear Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Methyl-CpG Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Oocyte Axis Specification Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	Protein Phosphorylation Signal Transduction Positive Regulation Of Chondrocyte Differentiation Tetrahydrobiopterin Metabolic Process Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization Negative Regulation Of Chloride Transport
Pathways		snRNP Assembly RMTs methylate histone arginines	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing
Drugs			Fostamatinib
Diseases
GWAS			Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 19343178 31562340 28552196 18391951 33713608 25282103 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Schizophrenia ( 33169155) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)
Interacting Genes		46 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 EIF4A1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PDCD4 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 UBC YWHAB YWHAQ ZMYND19 ZNF207	8 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS RAB11B WDR77
Entrez ID		79084	5593
HPRD ID		14387	09034
Ensembl ID		ENSG00000116455	ENSG00000138669
Uniprot IDs		A0A024R0H7 Q9BQA1	A0A140VJM3 B4DLF9 B7ZA25 Q13237
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R	5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Splicing MRNA Processing MRNA Metabolic Process Methylosome RNA Processing RNA Metabolic Process Spliceosomal Complex Assembly PICln-Sm Protein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Assembly Spliceosomal SnRNP Assembly U2 SnRNP Protein-RNA Complex Assembly Nucleic Acid Metabolic Process U2-type Spliceosomal Complex RNA Binding 7-methylguanosine Cap Hypermethylation U2-type Catalytic Step 2 Spliceosome U2-type Precatalytic Spliceosome Nucleoplasm U1 SnRNP Nucleus U4 SnRNP U12-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Precatalytic Spliceosome U5 SnRNP U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process U7 SnRNP Ribonucleoprotein Complex MRNA Binding Macromolecule Methylation Methylation RNA Methylation Commitment Complex Protein-containing Complex Assembly Nucleic Acid Binding Protein-containing Complex Organization RNA Modification CGMP-dependent Protein Kinase Activity MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Telomerase Holoenzyme Complex Histone Pre-mRNA DCP Binding	Cadherin Binding Monoatomic Ion Transport Postsynaptic Cytosol Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process 6-pyruvoyltetrahydropterin Synthase Activity Oocyte Axis Specification Actin Binding Cytoplasm Regulation Of Monoatomic Ion Transport Myosin Light Chain Kinase Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Phosphothreonine Residue Binding Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Cell Cortex Aorta Smooth Muscle Tissue Morphogenesis Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Metal Ion Transport Beta-2 Adrenergic Receptor Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Phosphatidylinositol Phospholipase C Activity Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Tetrahydrobiopterin Biosynthetic Process Constitutive Secretory Pathway Amyloid-beta Clearance By Transcytosis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cul4B-RING E3 Ubiquitin Ligase Complex Monoatomic Ion Transmembrane Transporter Activity Protein Modification Process Tonic Smooth Muscle Contraction Hypotonic Response Cellular Hypotonic Response Calmodulin Binding Bleb Assembly Sodium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transport Progesterone Receptor Signaling Pathway Endocardial Cushion Development Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway
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