WDR77 and PQBP1

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		WDR77	PQBP1
Description		WD repeat domain 77	polyglutamine binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cul4B-RING E3 Ubiquitin Ligase Complex Methylosome Transferase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Cytoplasmic Stress Granule Microtubule Cytoskeleton Nuclear Body Nuclear Speck Ciliary Basal Body Neuronal Ribonucleoprotein Granule Plasma Membrane Bounded Cell Projection
	Molecular Function	Transcription Coactivator Activity Protein Binding Methyl-CpG Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Protein Polyubiquitination Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Oocyte Axis Specification Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	Alternative MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Immune System Process Regulation Of DNA-templated Transcription MRNA Processing RNA Splicing Neuron Projection Development Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Dendrite Morphogenesis Defense Response To Virus Cellular Response To Exogenous DsRNA
Pathways		snRNP Assembly RMTs methylate histone arginines	mRNA Splicing - Major Pathway
Drugs
Diseases			Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Interacting Genes		46 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 EIF4A1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PDCD4 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 UBC YWHAB YWHAQ ZMYND19 ZNF207	27 interacting genes: APBB1 APP AQR ATXN1 CEBPA CLTB CPSF7 EEF1A1 ERG28 ESR1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RBM22 RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77
Entrez ID		79084	10084
HPRD ID		14387	02354
Ensembl ID		ENSG00000116455	ENSG00000102103
Uniprot IDs		A0A024R0H7 Q9BQA1	A0A0S2Z4V5 O60828
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R	4BWQ 4BWS 4CDO
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Splicing MRNA Processing MRNA Metabolic Process Methylosome RNA Processing RNA Metabolic Process Spliceosomal Complex Assembly PICln-Sm Protein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Assembly Spliceosomal SnRNP Assembly U2 SnRNP Protein-RNA Complex Assembly Nucleic Acid Metabolic Process U2-type Spliceosomal Complex RNA Binding 7-methylguanosine Cap Hypermethylation U2-type Catalytic Step 2 Spliceosome U2-type Precatalytic Spliceosome Nucleoplasm U1 SnRNP Nucleus U4 SnRNP U12-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Precatalytic Spliceosome U5 SnRNP U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process U7 SnRNP Ribonucleoprotein Complex MRNA Binding Macromolecule Methylation Methylation RNA Methylation Commitment Complex Protein-containing Complex Assembly Nucleic Acid Binding Protein-containing Complex Organization RNA Modification CGMP-dependent Protein Kinase Activity MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Telomerase Holoenzyme Complex Histone Pre-mRNA DCP Binding	Nucleoplasm Positive Regulation Of RNA Splicing
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