WDR77 and CDK19

Number of citations of the paper that reports this interaction (PubMedID 23749998)
61

Data Source:
BioGRID (affinity chromatography technology, pull down)

		WDR77	CDK19
Description		WD repeat domain 77	cyclin dependent kinase 19
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cul4B-RING E3 Ubiquitin Ligase Complex Methylosome Transferase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm CKM Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Methyl-CpG Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Oocyte Axis Specification Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	Positive Regulation Of Apoptotic Process Regulation Of Cell Cycle Cellular Response To Lipopolysaccharide
Pathways		snRNP Assembly RMTs methylate histone arginines	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS			General risk tolerance (MTAG) ( 30643258) Myeloperoxidase-DNA complexes ( 33717105) Zinc levels ( 26025379)
Interacting Genes		46 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 EIF4A1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PDCD4 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 UBC YWHAB YWHAQ ZMYND19 ZNF207	7 interacting genes: BCL6 EIF3F PRMT5 SMARCA4 SRSF7 SUZ12 WDR77
Entrez ID		79084	23097
HPRD ID		14387	07627
Ensembl ID		ENSG00000116455	ENSG00000155111
Uniprot IDs		A0A024R0H7 Q9BQA1	B4DUB1 F6QTA4 I6W807 Q9BWU1
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Splicing MRNA Processing MRNA Metabolic Process Methylosome RNA Processing RNA Metabolic Process Spliceosomal Complex Assembly PICln-Sm Protein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Assembly Spliceosomal SnRNP Assembly U2 SnRNP Protein-RNA Complex Assembly Nucleic Acid Metabolic Process U2-type Spliceosomal Complex RNA Binding 7-methylguanosine Cap Hypermethylation U2-type Catalytic Step 2 Spliceosome U2-type Precatalytic Spliceosome Nucleoplasm U1 SnRNP Nucleus U4 SnRNP U12-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Precatalytic Spliceosome U5 SnRNP U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process U7 SnRNP Ribonucleoprotein Complex MRNA Binding Macromolecule Methylation Methylation RNA Methylation Commitment Complex Protein-containing Complex Assembly Nucleic Acid Binding Protein-containing Complex Organization RNA Modification CGMP-dependent Protein Kinase Activity MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Telomerase Holoenzyme Complex Histone Pre-mRNA DCP Binding	Negative Regulation Of Gene Expression, Epigenetic Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Developmental Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RSC-type Complex Methylosome Negative Regulation Of Gene Expression Regulation Of RNA Splicing Methyl-CpG Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Transcription Corepressor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of MRNA Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle DNA Replication P53 Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Oocyte Axis Specification Chromatin DNA Binding Cysteine-type Deubiquitinase Activity Positive Regulation Of Cell Development Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Plasma Cell Differentiation Peptidyl-arginine N-methylation Regulation Of RNA Metabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication Isotype Switching To IgE Isotypes Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of T Cell Differentiation Chromatin Binding Regulation Of Mitotic Cell Cycle Intronic Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Biosynthetic Process Protein-containing Complex Assembly Cysteine-type Peptidase Activity
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