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WDR77 and NKX3-1
Number of citations of the paper that reports this interaction (PubMedID
12972618
)
58
Data Source:
BioGRID
(pull down)
WDR77
NKX3-1
Description
WD repeat domain 77
NK3 homeobox 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Cul4B-RING E3 Ubiquitin Ligase Complex
Methylosome
Transferase Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Site Of DNA Damage
Molecular Function
Transcription Coactivator Activity
Protein Binding
Methyl-CpG Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Nuclear Estrogen Receptor Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
MADS Box Domain Binding
DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Polyubiquitination
Spliceosomal SnRNP Assembly
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Oocyte Axis Specification
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of MRNA Splicing, Via Spliceosome
Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development
Epithelial Cell Proliferation Involved In Prostate Gland Development
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Negative Regulation Of Transcription By RNA Polymerase II
Urogenital System Development
Metanephros Development
Somitogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Salivary Gland Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Cell Differentiation
Androgen Receptor Signaling Pathway
Prostate Gland Development
Regulation Of Protein Localization
Response To Testosterone
Response To Lipid
Dorsal Aorta Development
Regulation Of Cell Population Proliferation
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Branching Morphogenesis Of An Epithelial Tube
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Division
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pharyngeal System Development
Branching Involved In Prostate Gland Morphogenesis
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Epithelial Cell Proliferation Involved In Prostate Gland Development
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Androgen Secretion
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
snRNP Assembly
RMTs methylate histone arginines
Drugs
Diseases
Prostate cancer
GWAS
Birth weight (
31043758
)
Mean corpuscular hemoglobin (
29403010
)
Mean corpuscular hemoglobin concentration (
29403010
)
Prostate cancer (
26443449
32986714
34012061
)
Prostate-specific antigen levels (
28139693
)
Waist-hip ratio (
25673412
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
46 interacting genes:
AQR
BAG2
CDK19
CDK8
CLNS1A
CREBBP
CTDP1
EIF4A1
GLI1
GPKOW
H2AC21
HNRNPM
LSM3
NKX3-1
PCBP2
PDCD4
PPIL1
PPP1R8
PQBP1
PRKG1
PRKG2
PRMT5
QKI
RBM5
SAP30BP
SF1
SF3A1
SF3B4
SIRT7
SMAD1
SMYD1
SNRPB
SNRPC
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SUZ12
THOC1
TOE1
UBC
YWHAB
YWHAQ
ZMYND19
ZNF207
38 interacting genes:
AEN
CCT7
CD200R1L
CENPX
CHPF
CKAP4
FEM1B
HIPK2
HMG20B
HNRNPA0
HSP90B1
LMCD1
MAN2B1
MNAT1
MRE11
MT-ND4
PEBP1
PTMS
RABL6
RARG
RHOXF2
RNF4
RPL37A
RPSA
SLC67A1
SP1
SP2
SP3
SP4
SP5
SPDEF
SRF
STMN3
TEX264
TOPORS
TPT1
WDR77
ZNF417
Entrez ID
79084
4824
HPRD ID
14387
03620
Ensembl ID
ENSG00000116455
ENSG00000167034
Uniprot IDs
A0A024R0H7
Q9BQA1
Q99801
PDB IDs
4GQB
4X60
4X61
4X63
5C9Z
5EMJ
5EMK
5EML
5EMM
5FA5
6CKC
6K1S
6RLL
6RLQ
6UGH
6UXX
6UXY
6V0N
6V0O
6V0P
7BO7
7KIB
7KIC
7KID
7L1G
7M05
7MX7
7MXA
7MXC
7MXG
7MXN
7S0U
7S1P
7S1Q
7S1R
7S1S
7SER
7SES
7U30
7UOH
7UY1
7UYF
7ZUP
7ZUQ
7ZUU
7ZUY
7ZV2
7ZVL
7ZVU
8CSG
8CTB
8CYI
8G1U
8VEO
8VET
8VEU
8VEW
8VEX
8VEY
8X6L
9C10
9DOD
9E3A
9E3B
9EYU
9EYV
9EYW
9EYX
9MGL
9MGM
9MGN
9MGP
9MGQ
9MGR
9N3N
9N3O
9N3P
9N3Q
9N3R
2L9R
Enriched GO Terms of Interacting Partners
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MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Spliceosomal Complex
RNA Splicing
MRNA Processing
MRNA Metabolic Process
Methylosome
RNA Processing
RNA Metabolic Process
Spliceosomal Complex Assembly
PICln-Sm Protein Complex
Catalytic Step 2 Spliceosome
U2-type Prespliceosome Assembly
Spliceosomal SnRNP Assembly
U2 SnRNP
Protein-RNA Complex Assembly
Nucleic Acid Metabolic Process
U2-type Spliceosomal Complex
RNA Binding
7-methylguanosine Cap Hypermethylation
U2-type Catalytic Step 2 Spliceosome
U2-type Precatalytic Spliceosome
Nucleoplasm
U1 SnRNP
Nucleus
U4 SnRNP
U12-type Spliceosomal Complex
Nucleobase-containing Compound Metabolic Process
Small Nuclear Ribonucleoprotein Complex
SMN-Sm Protein Complex
Precatalytic Spliceosome
U5 SnRNP
U4/U6 X U5 Tri-snRNP Complex
Macromolecule Metabolic Process
U7 SnRNP
Ribonucleoprotein Complex
MRNA Binding
Macromolecule Methylation
Methylation
RNA Methylation
Commitment Complex
Protein-containing Complex Assembly
Nucleic Acid Binding
Protein-containing Complex Organization
RNA Modification
CGMP-dependent Protein Kinase Activity
MRNA Cis Splicing, Via Spliceosome
U2-type Prespliceosome
Telomerase Holoenzyme Complex
Histone Pre-mRNA DCP Binding
Nucleus
DNA Binding
PML Body
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Trachea Cartilage Development
Sequence-specific Double-stranded DNA Binding
Embryonic Eye Morphogenesis
Glandular Epithelial Cell Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Sequence-specific DNA Binding
Chromatin
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Apoptotic Process
Double-stranded DNA Binding
Regulation Of Programmed Cell Death
DNA Damage Response
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Eye Morphogenesis
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Sensory Organ Morphogenesis
Columnar/cuboidal Epithelial Cell Development
Embryonic Camera-type Eye Morphogenesis
Zinc Ion Binding
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Trophectodermal Cell Differentiation
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Face Development
Regulation Of Macromolecule Biosynthetic Process
Prostate Gland Epithelium Morphogenesis
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Macromolecule Metabolic Process
Signal Transduction By P53 Class Mediator
Cellular Response To Stress
Replication Fork
Positive Regulation Of Macromolecule Metabolic Process
Mitochondrial Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Hydrogen Sulfide Biosynthetic Process
Cellular Response To Wortmannin
Thyroid Gland Development
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Tagcloud (Intersection)
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