PCNA and GCK

Number of citations of the paper that reports this interaction (PubMedID 20849852)
0

Data Source:
BioGRID (pull down)

		PCNA	GCK
Description		proliferating cell nuclear antigen	glucokinase
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Chromatin Male Germ Cell Nucleus Nucleus Nuclear Lamina Nucleoplasm Replication Fork Centrosome Nuclear Body Replisome Nuclear Replication Fork PCNA Complex Extracellular Exosome PCNA-p21 Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Binding Chromatin Binding Damaged DNA Binding Protein Binding Enzyme Binding Nuclear Estrogen Receptor Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Histone Acetyltransferase Binding Identical Protein Binding Protein-containing Complex Binding DNA Polymerase Binding	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity Glucose Sensor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Leading Strand Elongation Regulation Of DNA Replication DNA Repair Base-excision Repair, Gap-filling Mismatch Repair Chromatin Organization DNA Damage Response Response To Oxidative Stress Heart Development Translesion Synthesis Epithelial Cell Differentiation Replication Fork Processing Positive Regulation Of Deoxyribonuclease Activity Response To Estradiol Response To Lipid Cellular Response To UV Estrous Cycle Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Response To Cadmium Ion Cellular Response To Hydrogen Peroxide Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Liver Regeneration Positive Regulation Of DNA-directed DNA Polymerase Activity Response To L-glutamate Mitotic Telomere Maintenance Via Semi-conservative Replication	Intracellular Glucose Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Glucose Catabolic Process Glycolytic Process Regulation Of Glycolytic Process Purine Nucleotide Metabolic Process NADP+ Metabolic Process Response To Glucose Hexose Metabolic Process Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Glucose Homeostasis Regulation Of Potassium Ion Transport Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Calcium Ion Import
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Transcription of E2F targets under negative control by DREAM complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand SUMOylation of DNA replication proteins Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription E3 ubiquitin ligases ubiquitinate target proteins	Regulation of Glucokinase by Glucokinase Regulatory Protein Regulation of gene expression in beta cells Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Liothyronine Acetylsalicylic acid	Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases			Permanent neonatal diabetes mellitus (PNDM) Maturity onset diabetes of the young (MODY)
GWAS			Birth weight ( 27680694 31043758) Blood glucose levels ( 31928498) Blood sugar levels ( 29403010) Coronary artery disease and triglyceride levels (multivariate analysis) ( 30525989) Fasting blood glucose ( 20081858 25631608 33842983 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting plasma glucose ( 19060907 25187374) Fructosamine levels ( 34753797) Glycated hemoglobin levels ( 31213470 34059833 19096518 28898252 24647736 20858683 24244560) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) HOMA-B (corrected for HOMA-IR) ( 30369944) Homeostasis model assessment of beta-cell function ( 20081858) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109 23823483) Offspring birth weight ( 31043758 29309628) Pulse pressure ( 27841878 30578418) Triglyceride levels ( 31928498 32154731 32203549) Triglycerides ( 30275531) Two-hour glucose ( 34059833) Type 2 diabetes ( 30718926 22885922 32499647 30297969)
Interacting Genes		142 interacting genes: ALDOA APEX1 APEX2 ATAD5 ATM BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 CMTM5 CREBBP DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 ERCC6 ERRFI1 ESCO2 EXO1 FAN1 FANCD2 FANCL FBH1 FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HUS1 ING1 KCTD13 KMT5A LDHA LIG1 MCL1 MGMT MLH1 MLH3 MSH2 MSH3 MSH6 MTOR MUTYH MYBBP1A NEDD8 NIPBL NMRAL1 NSD2 NTHL1 NUTF2 PARP1 PARP10 PARPBP PCLAF PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLK POLL POLM PPP1CA PRKDC PTEN PTMA RAD18 RAD9A RBBP8 RECQL5 RFC1 RFC2 RFC3 RFC4 RFC5 RFWD3 RPA1 S100A8 SDE2 SEC23IP SIVA1 SLC30A8 SMARCAD1 SPG21 SUB1 SUMO1 TCOF1 TDG TIRAP TMEM218 TPI1 UBB UBC UBE2A UBE2B UBE2D3 UBE2I UBE3D UHRF1 UNG USP4 WDR48 WRN XPA XRCC1 XRCC5 XRCC6 YBX1 ZBTB1	7 interacting genes: GCKR INS PCNA PFKFB2 PFKFB3 PRKN SPDYE4
Entrez ID		5111	2645
HPRD ID		01456	00680
Ensembl ID		ENSG00000132646	ENSG00000106633
Uniprot IDs		P12004	A0A5F9ZGW4 H7BXV0 P35557 Q53Y25
PDB IDs		1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3JA9 3P87 3TBL 3VKX 3WGW 4D2G 4RJF 4ZTD 5E0T 5E0U 5E0V 5IY4 5MAV 5MLO 5MLW 5MOM 5YCO 5YD8 6CBI 6EHT 6FCM 6FCN 6GIS 6GWS 6HVO 6K3A 6QC0 6QCG 6S1M 6S1N 6S1O 6TNY 6TNZ 6VVO 7EFA 7KQ0 7KQ1 7M5L 7M5M 7M5N 7NV0 7NV1 7QNZ 7QO1 8B8T 8COB 8E84 8F5Q 8GCJ 8GL9 8GLA 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8YJH 8YJL 8YJQ 8YJR 8YJS 8YJU 8YJV 8YJW 8YJZ 9B8S 9B8T 9CG4 9CHM 9CL7 9CMA 9EOA 9F6D 9F6E 9F6F 9GY0	1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I 7T78 7T79
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Nucleus Nucleoplasm Response To Stress DNA Replication DNA Recombination Macromolecule Metabolic Process Damaged DNA Binding Double-strand Break Repair DNA Biosynthetic Process Regulation Of DNA Metabolic Process Response To Radiation DNA Binding Postreplication Repair Response To UV Positive Regulation Of DNA Metabolic Process DNA Synthesis Involved In DNA Repair Recombinational Repair Base-excision Repair Chromosome Organization DNA-templated DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Mismatch Repair DNA-directed DNA Polymerase Activity Response To Light Stimulus Translesion Synthesis Somatic Hypermutation Of Immunoglobulin Genes Regulation Of DNA Recombination Negative Regulation Of Metabolic Process DNA Clamp Loader Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Somatic Diversification Of Immunoglobulins Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of DNA Metabolic Process DNA Polymerase Activity Somatic Cell DNA Recombination Ctf18 RFC-like Complex Glycolytic Process	Negative Regulation Of Glucokinase Activity 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Fructose Metabolic Process Glucose Metabolic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Response To L-glutamate Positive Regulation Of Mitochondrial Fission Carbohydrate Phosphorylation Hexose Metabolic Process Monosaccharide Metabolic Process Regulation Of Catalytic Activity Regulation Of Secretion By Cell Regulation Of Mitochondrial Fission Regulation Of Peptide Hormone Secretion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Secretion Positive Regulation Of ATP Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Glycolytic Process ADP Catabolic Process Gluconeogenesis Purine Ribonucleoside Diphosphate Catabolic Process Positive Regulation Of Secretion By Cell ADP Metabolic Process Hexose Biosynthetic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Pyruvate Metabolic Process Negative Regulation Of Spontaneous Neurotransmitter Secretion PCNA Complex Replisome Negative Regulation Of Protein Secretion Regulation Of ATP Metabolic Process Negative Regulation Of Kinase Activity Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process
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