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PCNA and XRCC6
Number of citations of the paper that reports this interaction (PubMedID
11239001
)
55
Data Source:
HPRD
(in vitro, in vivo)
PCNA
XRCC6
Description
proliferating cell nuclear antigen
X-ray repair cross complementing 6
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Chromatin
Male Germ Cell Nucleus
Nucleus
Nuclear Lamina
Nucleoplasm
Replication Fork
Centrosome
Nuclear Body
Replisome
Nuclear Replication Fork
PCNA Complex
Extracellular Exosome
PCNA-p21 Complex
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Cytoplasm
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Ficolin-1-rich Granule Lumen
Molecular Function
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
DNA Binding
Chromatin Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Nuclear Estrogen Receptor Binding
DNA Polymerase Processivity Factor Activity
Receptor Tyrosine Kinase Binding
Dinucleotide Insertion Or Deletion Binding
MutLalpha Complex Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Nucleotide Binding
Transcription Cis-regulatory Region Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Catalytic Activity
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
Lyase Activity
ATP Hydrolysis Activity
Cyclin Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Scaffold Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Replication
Leading Strand Elongation
Regulation Of DNA Replication
DNA Repair
Base-excision Repair, Gap-filling
Mismatch Repair
Chromatin Organization
DNA Damage Response
Response To Oxidative Stress
Heart Development
Translesion Synthesis
Epithelial Cell Differentiation
Replication Fork Processing
Positive Regulation Of Deoxyribonuclease Activity
Response To Estradiol
Response To Lipid
Cellular Response To UV
Estrous Cycle
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Response To Cadmium Ion
Cellular Response To Hydrogen Peroxide
Cellular Response To Xenobiotic Stimulus
Response To Dexamethasone
Liver Regeneration
Positive Regulation Of DNA-directed DNA Polymerase Activity
Response To L-glutamate
Mitotic Telomere Maintenance Via Semi-conservative Replication
Telomere Maintenance
Recombinational Repair
Activation Of Innate Immune Response
Immune System Process
Positive Regulation Of Immune System Process
DNA Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Response To Ionizing Radiation
Negative Regulation Of Macromolecule Biosynthetic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Smooth Muscle Cell Proliferation
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Transcription of E2F targets under negative control by DREAM complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA replication proteins
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
E3 ubiquitin ligases ubiquitinate target proteins
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Drugs
Liothyronine
Acetylsalicylic acid
Diseases
GWAS
Asthma (
34103634
)
Breast cancer (
29059683
)
Meat-related diet (
32066663
)
Neuroticism (
29255261
)
Pulse pressure (
28135244
)
Refractive error (
32231278
)
Interacting Genes
142 interacting genes:
ALDOA
APEX1
APEX2
ATAD5
ATM
BAZ1B
CBX1
CCNB1
CCND1
CCND3
CCNO
CDC25C
CDC6
CDK1
CDK2
CDK5
CDK6
CDKN1A
CDKN1C
CDKN2A
CDT1
CHAF1A
CHTF18
CHTF8
CMTM5
CREBBP
DHX9
DNMT1
DNTT
DNTTIP2
DSCC1
DTL
EGFR
ENO1
EP300
ERCC5
ERCC6
ERRFI1
ESCO2
EXO1
FAN1
FANCD2
FANCL
FBH1
FEN1
GADD45A
GADD45B
GADD45G
GAPDH
GCK
GPI
HDAC1
HUS1
ING1
KCTD13
KMT5A
LDHA
LIG1
MCL1
MGMT
MLH1
MLH3
MSH2
MSH3
MSH6
MTOR
MUTYH
MYBBP1A
NEDD8
NIPBL
NMRAL1
NSD2
NTHL1
NUTF2
PARP1
PARP10
PARPBP
PCLAF
PFKM
PGAM1
PGK1
PKLR
PMS2
POLB
POLD1
POLD2
POLD3
POLD4
POLDIP2
POLE
POLH
POLI
POLK
POLL
POLM
PPP1CA
PRKDC
PTEN
PTMA
RAD18
RAD9A
RBBP8
RECQL5
RFC1
RFC2
RFC3
RFC4
RFC5
RFWD3
RPA1
S100A8
SDE2
SEC23IP
SIVA1
SLC30A8
SMARCAD1
SPG21
SUB1
SUMO1
TCOF1
TDG
TIRAP
TMEM218
TPI1
UBB
UBC
UBE2A
UBE2B
UBE2D3
UBE2I
UBE3D
UHRF1
UNG
USP4
WDR48
WRN
XPA
XRCC1
XRCC5
XRCC6
YBX1
ZBTB1
144 interacting genes:
ABCD4
ABL1
ACD
ADCY7
ANXA1
APEX1
AR
ARAP1
ATP23
ATP6V1E1
BARD1
BAZ1A
BTG1
CAPN11
CBX5
CCNA1
CCNB1
CCT3
CD40
CDCA5
CDK1
CDK2
CDKN1A
CEBPA
CENPU
CHAF1A
CHEK1
CLTC
CLU
CMTM6
COIL
COPB1
CREBBP
CSNK2A1
CTBP2
DEAF1
DLX2
DNTT
DSCR4
DUX4
DYRK1A
DYSF
EFNA1
EGFR
EID1
EIF4ENIF1
ELF3
EP300
EPS8
ETS1
FCER2
FILNC1
FMNL1
GAL3ST4
GSE1
GZMA
GZMB
HACL2
HERPUD1
HOXB7
HOXC4
HOXD4
HSF1
HTT
JPT2
KAT2A
KAT2B
KIAA0408
LIG3
MAP2K5
MAP4K2
MAPK8
MRE11
MSX2
NAA15
NCF4
NCL
NCOA6
NIT1
NOTCH1
OGT
PAEP
PAFAH1B3
PARP1
PCNA
PDK1
PDPK1
PDX1
PECAM1
PGAM1
PGR
PIN1
PLGRKT
PNRC2
POR
POU2F1
POU2F2
PRKDC
PRPF40A
PTEN
PTTG1
QRSL1
RASA1
RBBP4
RGS2
RNF10
RNF126
RNF146
RPLP1
RPS10
RRAS2
RUNX2
SDHC
SELENOF
SERPINA2
SERPINB9
SET
SGO1
SIRT3
SKIL
SMAD3
SMAD7
SNTA1
SNU13
SPARC
SUMO2
TAC1
TADA3
TBCD
TCF4
TERF2
TERT
TP53
UBC
USP14
VAV1
VBP1
WBP4
WEE2-AS1
WRN
XRCC5
YWHAZ
ZBTB7A
ZNF512B
Entrez ID
5111
2547
HPRD ID
01456
01071
Ensembl ID
ENSG00000132646
ENSG00000196419
Uniprot IDs
P12004
B1AHC9
B4DE32
B4E356
P12956
PDB IDs
1AXC
1U76
1U7B
1UL1
1VYJ
1VYM
1W60
2ZVK
2ZVL
2ZVM
3JA9
3P87
3TBL
3VKX
3WGW
4D2G
4RJF
4ZTD
5E0T
5E0U
5E0V
5IY4
5MAV
5MLO
5MLW
5MOM
5YCO
5YD8
6CBI
6EHT
6FCM
6FCN
6GIS
6GWS
6HVO
6K3A
6QC0
6QCG
6S1M
6S1N
6S1O
6TNY
6TNZ
6VVO
7EFA
7KQ0
7KQ1
7M5L
7M5M
7M5N
7NV0
7NV1
7QNZ
7QO1
8B8T
8COB
8E84
8F5Q
8GCJ
8GL9
8GLA
8UI7
8UI8
8UI9
8UII
8UMT
8UMU
8UMV
8UMW
8UMY
8UN0
8YJH
8YJL
8YJQ
8YJR
8YJS
8YJU
8YJV
8YJW
8YJZ
9B8S
9B8T
9CG4
9CHM
9CL7
9CMA
9EOA
9F6D
9F6E
9F6F
9GY0
1JEQ
1JEY
1JJR
3RZX
5Y3R
6ERF
6ERG
6ERH
6ZHA
6ZHE
7AXZ
7K0Y
7K1J
7K1K
7K1N
7LSY
7LT3
7NFC
7NFE
7SGL
7SU3
7Z6O
7Z87
7Z88
7ZT6
7ZVT
7ZWA
7ZYG
8AG4
8AG5
8ASC
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
8RD4
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Nucleus
Nucleoplasm
Response To Stress
DNA Replication
DNA Recombination
Macromolecule Metabolic Process
Damaged DNA Binding
Double-strand Break Repair
DNA Biosynthetic Process
Regulation Of DNA Metabolic Process
Response To Radiation
DNA Binding
Postreplication Repair
Response To UV
Positive Regulation Of DNA Metabolic Process
DNA Synthesis Involved In DNA Repair
Recombinational Repair
Base-excision Repair
Chromosome Organization
DNA-templated DNA Replication
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Mismatch Repair
DNA-directed DNA Polymerase Activity
Response To Light Stimulus
Translesion Synthesis
Somatic Hypermutation Of Immunoglobulin Genes
Regulation Of DNA Recombination
Negative Regulation Of Metabolic Process
DNA Clamp Loader Activity
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Regulation Of Cell Cycle Phase Transition
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Primary Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
Somatic Diversification Of Immunoglobulins
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of DNA Metabolic Process
DNA Polymerase Activity
Somatic Cell DNA Recombination
Ctf18 RFC-like Complex
Glycolytic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Nucleoplasm
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
DNA Damage Response
Cellular Response To Stress
Response To Stress
DNA Metabolic Process
DNA Repair
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Nucleus
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin Binding
Regulation Of Programmed Cell Death
Negative Regulation Of RNA Metabolic Process
Regulation Of Cellular Response To Stress
Chromosome, Telomeric Region
Protein-containing Complex
Regulation Of Protein Stability
Chromatin
Negative Regulation Of Programmed Cell Death
Double-strand Break Repair
Negative Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Regulation Of DNA Repair
Negative Regulation Of Apoptotic Process
Positive Regulation Of DNA Metabolic Process
Nucleic Acid Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
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