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PCNA and POLD2
Number of citations of the paper that reports this interaction (PMID
12171929
)
18
Data Source:
HPRD
(in vivo, in vitro)
PCNA
POLD2
Gene Name
proliferating cell nuclear antigen
polymerase (DNA directed), delta 2, accessory subunit
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
DNA Replication Factor C Complex
Cytoplasm
Centrosome
Nuclear Replication Fork
PCNA Complex
Extracellular Vesicular Exosome
PCNA-p21 Complex
Nucleus
Nucleoplasm
Molecular Function
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Protein Binding
DNA Polymerase Processivity Factor Activity
Receptor Tyrosine Kinase Binding
Dinucleotide Insertion Or Deletion Binding
MutLalpha Complex Binding
Identical Protein Binding
DNA Polymerase Binding
DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Regulation Of DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Heart Development
Cell Proliferation
Translesion Synthesis
Epithelial Cell Differentiation
Positive Regulation Of Deoxyribonuclease Activity
Telomere Maintenance Via Semi-conservative Replication
Response To Lipid
Response To Cadmium Ion
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
Pathways
Nucleotide Excision Repair
Gap-filling DNA repair synthesis and ligation in TC-NER
Extension of Telomeres
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Leading Strand Synthesis
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
DNA strand elongation
Mismatch Repair
Polymerase switching
Telomere Maintenance
G1/S Transition
Removal of DNA patch containing abasic residue
G1/S-Specific Transcription
Resolution of Abasic Sites (AP sites)
Mitotic G1-G1/S phases
Removal of the Flap Intermediate from the C-strand
Base Excision Repair
E2F mediated regulation of DNA replication
Polymerase switching on the C-strand of the telomere
Chromosome Maintenance
Synthesis of DNA
Lagging Strand Synthesis
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
G0 and Early G1
Telomere C-strand (Lagging Strand) Synthesis
S Phase
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Removal of the Flap Intermediate
Global Genomic NER (GG-NER)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Transcription-coupled NER (TC-NER)
Nucleotide Excision Repair
Gap-filling DNA repair synthesis and ligation in TC-NER
Extension of Telomeres
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Leading Strand Synthesis
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
DNA strand elongation
Mismatch Repair
Polymerase switching
Telomere Maintenance
Removal of DNA patch containing abasic residue
Resolution of Abasic Sites (AP sites)
Removal of the Flap Intermediate from the C-strand
Base Excision Repair
Polymerase switching on the C-strand of the telomere
Synthesis of DNA
Chromosome Maintenance
Lagging Strand Synthesis
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
S Phase
Telomere C-strand (Lagging Strand) Synthesis
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Removal of the Flap Intermediate
Global Genomic NER (GG-NER)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions
116 interactors:
ALDOA
APEX1
APEX2
ATAD5
BAZ1B
CBX1
CCNB1
CCND1
CCND3
CCNO
CDC25C
CDC6
CDK1
CDK2
CDK5
CDK6
CDKN1A
CDKN1C
CDKN2A
CDT1
CHAF1A
CHTF18
CHTF8
DHX9
DNMT1
DNTT
DNTTIP2
DSCC1
DTL
EGFR
ENO1
EP300
ERCC5
EXO1
FANCD2
FANCL
FEN1
GADD45A
GADD45B
GADD45G
GAPDH
GCK
GPI
HDAC1
HLTF
HUS1
ING1
KCTD13
LDHA
LIG1
MCL1
MLH1
MSH2
MSH3
MSH6
MUTYH
MYBBP1A
PARP1
PARP10
PFKM
PGAM1
PGK1
PKLR
PMS2
POLB
POLD1
POLD2
POLD3
POLD4
POLDIP2
POLE
POLH
POLI
POLL
POLM
PPP1CA
PRKDC
PTMA
RAD18
RAD9A
RBBP8
RFC1
RFC2
RFC3
RFC4
RFC5
RNF8
RPA1
SEC23IP
SETD8
SHPRH
SIVA1
SMARCAD1
SPRTN
SUB1
TCOF1
TDG
TIRAP
TMEM218
TPI1
UBB
UBE2A
UBE2B
UBE2D3
UHRF2
UNG
USP1
USP2
USP4
WDR48
WRN
XRCC1
XRCC5
XRCC6
YBX1
ZBTB1
16 interactors:
CCHCR1
CDK2
CDKN1A
EP300
KCTD13
LSM6
PCNA
POLD1
POLD3
POLD4
POLDIP2
POLDIP3
SOX12
WRN
WRNIP1
XRN1
Entrez ID
5111
5425
HPRD ID
01456
15982
Ensembl ID
ENSG00000132646
ENSG00000106628
Uniprot IDs
P12004
A4D2J4
B2R5S4
P49005
PDB IDs
1AXC
1U76
1U7B
1UL1
1VYJ
1VYM
1W60
2ZVK
2ZVL
2ZVM
3P87
3TBL
3VKX
3E0J
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
DNA Repair
Cellular Response To DNA Damage Stimulus
Cellular Response To Stress
Nucleobase-containing Compound Metabolic Process
Response To Stress
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cell Cycle
DNA Recombination
Cellular Nitrogen Compound Metabolic Process
DNA Replication
Nitrogen Compound Metabolic Process
Cell Cycle Process
Chromosome Organization
Base-excision Repair
Cellular Metabolic Process
Telomere Maintenance Via Semi-conservative Replication
Telomere Maintenance
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Recombination
Nuclear DNA Replication
Mitotic Cell Cycle
Mitotic Recombination
Mismatch Repair
Telomere Maintenance Via Telomere Lengthening
DNA Biosynthetic Process
DNA Strand Elongation Involved In DNA Replication
Transcription-coupled Nucleotide-excision Repair
DNA Strand Elongation
Cellular Response To Stimulus
Response To Radiation
Response To Stimulus
Organelle Organization
DNA-dependent DNA Replication
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Biosynthetic Process
Response To UV
Double-strand Break Repair
Nucleotide-excision Repair
Response To Abiotic Stimulus
Catabolic Process
Somatic Diversification Of Immunoglobulins
Somatic Hypermutation Of Immunoglobulin Genes
Negative Regulation Of Cellular Metabolic Process
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Regulation Of Cell Cycle
Response To Light Stimulus
Cellular Macromolecule Catabolic Process
DNA Replication
DNA Biosynthetic Process
DNA Synthesis Involved In DNA Repair
Nucleotide-excision Repair, DNA Gap Filling
Base-excision Repair
Telomere Maintenance Via Semi-conservative Replication
Cellular Response To DNA Damage Stimulus
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Telomere Maintenance
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
DNA-dependent DNA Replication
Transcription-coupled Nucleotide-excision Repair
DNA Repair
Mismatch Repair
Chromosome Organization
Cellular Response To Stress
DNA Metabolic Process
Mitotic Cell Cycle
DNA Recombination
Nucleotide-excision Repair
Regulation Of DNA Replication
Nucleobase-containing Compound Metabolic Process
Cell Cycle Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Organelle Organization
Regulation Of DNA-dependent DNA Replication Initiation
Cell Cycle
Response To Stress
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Macromolecule Biosynthetic Process
Signal Transduction By P53 Class Mediator
G2/M Transition Of Mitotic Cell Cycle
Response To UV
Positive Regulation Of DNA Metabolic Process
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Mitochondrion Morphogenesis
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
G1/S Transition Of Mitotic Cell Cycle
Cellular Macromolecule Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Biosynthetic Process
Tagcloud
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12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Difference)
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Intersection)
?