PCNA and LIG1

Number of citations of the paper that reports this interaction (PMID 10559261)
27

Data Source:
HPRD (in vitro)

		PCNA	LIG1
Gene Name		proliferating cell nuclear antigen	ligase I, DNA, ATP-dependent
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Cytoplasm Centrosome Nuclear Replication Fork PCNA Complex Extracellular Vesicular Exosome PCNA-p21 Complex	Nucleus Nucleoplasm Chromosome Mitochondrion Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Identical Protein Binding DNA Polymerase Binding	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Regulation Of DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Heart Development Cell Proliferation Translesion Synthesis Epithelial Cell Differentiation Positive Regulation Of Deoxyribonuclease Activity Telomere Maintenance Via Semi-conservative Replication Response To Lipid Response To Cadmium Ion	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication Lagging Strand Elongation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Anatomical Structure Morphogenesis Telomere Maintenance Via Semi-conservative Replication V(D)J Recombination Response To Hydrogen Peroxide DNA Ligation Involved In DNA Repair Cell Division DNA Biosynthetic Process
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance G1/S Transition Removal of DNA patch containing abasic residue G1/S-Specific Transcription Resolution of Abasic Sites (AP sites) Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Base Excision Repair E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand G0 and Early G1 Telomere C-strand (Lagging Strand) Synthesis S Phase Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)	Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Telomere Maintenance Removal of DNA patch containing abasic residue Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Resolution of D-loop structures through Holliday junction intermediates Resolution of Abasic Sites (AP sites) Base Excision Repair Resolution of D-loop structures Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand Processive synthesis on the C-strand of the telomere S Phase Telomere C-strand (Lagging Strand) Synthesis Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER) Homologous Recombination Repair
Drugs			Bleomycin
Diseases
GWAS
Protein-Protein Interactions		116 interactors: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 EXO1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HLTF HUS1 ING1 KCTD13 LDHA LIG1 MCL1 MLH1 MSH2 MSH3 MSH6 MUTYH MYBBP1A PARP1 PARP10 PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLL POLM PPP1CA PRKDC PTMA RAD18 RAD9A RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RNF8 RPA1 SEC23IP SETD8 SHPRH SIVA1 SMARCAD1 SPRTN SUB1 TCOF1 TDG TIRAP TMEM218 TPI1 UBB UBE2A UBE2B UBE2D3 UHRF2 UNG USP1 USP2 USP4 WDR48 WRN XRCC1 XRCC5 XRCC6 YBX1 ZBTB1	6 interactors: CSNK2A1 INPP1 MRE11A PCNA RGS2 TUBB3
Entrez ID		5111	3978
HPRD ID		01456	00534
Ensembl ID		ENSG00000132646	ENSG00000105486
Uniprot IDs		P12004	B4DTU4 F5GZ28 P18858
PDB IDs		1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3P87 3TBL 3VKX	1X9N
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Cell Cycle Process Chromosome Organization Base-excision Repair Cellular Metabolic Process Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Recombination Nuclear DNA Replication Mitotic Cell Cycle Mitotic Recombination Mismatch Repair Telomere Maintenance Via Telomere Lengthening DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Strand Elongation Cellular Response To Stimulus Response To Radiation Response To Stimulus Organelle Organization DNA-dependent DNA Replication Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To UV Double-strand Break Repair Nucleotide-excision Repair Response To Abiotic Stimulus Catabolic Process Somatic Diversification Of Immunoglobulins Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Cellular Metabolic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Cycle Response To Light Stimulus Cellular Macromolecule Catabolic Process	Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Cycle Process Base-excision Repair Telomere Maintenance Nucleotide-excision Repair Positive Regulation Of Deoxyribonuclease Activity Regulation Of DNA Replication Leading Strand Elongation Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Endoreduplication Negative Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Cell Cycle Checkpoint Regulation Of Mitotic Recombination Regulation Of Adrenergic Receptor Signaling Pathway DNA Recombination Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity DNA Replication Protein Folding Intra-S DNA Damage Checkpoint Relaxation Of Vascular Smooth Muscle Regulation Of DNA Endoreduplication Relaxation Of Smooth Muscle Telomere Maintenance Via Telomerase Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Translesion Synthesis Negative Regulation Of Muscle Hypertrophy Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Negative Regulation Of Smooth Muscle Contraction Axon Guidance Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Hydrolase Activity Nucleotide-excision Repair, DNA Gap Filling Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Cell Differentiation Positive Regulation Of Metabolic Process Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Cell Cycle Negative Regulation Of Lipase Activity Postreplication Repair Negative Regulation Of Muscle Contraction
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	24h 300mum 513a 5p abp aminobiphenyl array arrays arylamine bioinformatic carcinogen comet damage deregulation eventually exo1 fancg hepg2 mirna mirnas parallel pcna pcr qrt rad18 repair ung validated xrcc2
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	24h 300mum 513a 5p abp aminobiphenyl array arrays arylamine bioinformatic carcinogen comet damage deregulation eventually exo1 fancg hepg2 mirna mirnas parallel pcna pcr qrt rad18 repair ung validated xrcc2
Tagcloud (Intersection) ?