PCNA and SETD8

Number of citations of the paper that reports this interaction (PMID 22556262)
10

Data Source:
BioGRID (enzymatic study)

		PCNA	SETD8
Gene Name		proliferating cell nuclear antigen	SET domain containing (lysine methyltransferase) 8
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Cytoplasm Centrosome Nuclear Replication Fork PCNA Complex Extracellular Vesicular Exosome PCNA-p21 Complex	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Identical Protein Binding DNA Polymerase Binding	P53 Binding Transcription Corepressor Activity Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Regulation Of DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Heart Development Cell Proliferation Translesion Synthesis Epithelial Cell Differentiation Positive Regulation Of Deoxyribonuclease Activity Telomere Maintenance Via Semi-conservative Replication Response To Lipid Response To Cadmium Ion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Mitotic Nuclear Division Peptidyl-lysine Monomethylation Histone Lysine Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription, DNA-templated Cell Division
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance G1/S Transition Removal of DNA patch containing abasic residue G1/S-Specific Transcription Resolution of Abasic Sites (AP sites) Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Base Excision Repair E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand G0 and Early G1 Telomere C-strand (Lagging Strand) Synthesis S Phase Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)	Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		116 interactors: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 EXO1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HLTF HUS1 ING1 KCTD13 LDHA LIG1 MCL1 MLH1 MSH2 MSH3 MSH6 MUTYH MYBBP1A PARP1 PARP10 PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLL POLM PPP1CA PRKDC PTMA RAD18 RAD9A RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RNF8 RPA1 SEC23IP SETD8 SHPRH SIVA1 SMARCAD1 SPRTN SUB1 TCOF1 TDG TIRAP TMEM218 TPI1 UBB UBE2A UBE2B UBE2D3 UHRF2 UNG USP1 USP2 USP4 WDR48 WRN XRCC1 XRCC5 XRCC6 YBX1 ZBTB1	9 interactors: DTL E2F2 FAM9A HIST4H4 LEF1 PCNA TP53 TWIST1 UBE2I
Entrez ID		5111	387893
HPRD ID		01456	06254
Ensembl ID		ENSG00000132646	ENSG00000183955
Uniprot IDs		P12004	E3VVS3 Q9NQR1
PDB IDs		1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3P87 3TBL 3VKX	1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Cell Cycle Process Chromosome Organization Base-excision Repair Cellular Metabolic Process Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Recombination Nuclear DNA Replication Mitotic Cell Cycle Mitotic Recombination Mismatch Repair Telomere Maintenance Via Telomere Lengthening DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Strand Elongation Cellular Response To Stimulus Response To Radiation Response To Stimulus Organelle Organization DNA-dependent DNA Replication Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To UV Double-strand Break Repair Nucleotide-excision Repair Response To Abiotic Stimulus Catabolic Process Somatic Diversification Of Immunoglobulins Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Cellular Metabolic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Cycle Response To Light Stimulus Cellular Macromolecule Catabolic Process	Cell Cycle Mitotic Cell Cycle Translesion Synthesis DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Postreplication Repair Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction By P53 Class Mediator Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Gene Expression Negative Regulation Of Striated Muscle Tissue Development Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Neural Crest Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Muscle Organ Development Positive Regulation Of Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Epithelial To Mesenchymal Transition Base-excision Repair Chromosome Organization T Cell Activation Involved In Immune Response Neural Crest Cell Development Cell Cycle Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Epithelium Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Telomere Maintenance Neural Crest Cell Differentiation Somitogenesis Positive Regulation Of Deoxyribonuclease Activity Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Positive Regulation Of SUMO Transferase Activity
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	5a battery biophysical catalyzes competitive comprehensive discovery extensively h4 h4k20 interesting kmt5a lysine methyltransferase methyltransferases monomethylates monomethylation pcna potencies proliferating pursued quinazoline sar scaffold set7 set8 substituents trends unc0379
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	5a battery biophysical catalyzes competitive comprehensive discovery extensively h4 h4k20 interesting kmt5a lysine methyltransferase methyltransferases monomethylates monomethylation pcna potencies proliferating pursued quinazoline sar scaffold set7 set8 substituents trends unc0379
Tagcloud (Intersection) ?