RPA1 and RAD23B

Number of citations of the paper that reports this interaction (PMID 15914671)
32

Data Source:
BioGRID (pull down)

		RPA1	RAD23B
Gene Name		replication protein A1, 70kDa	RAD23 homolog B (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body	Proteasome Complex Nucleus Nucleoplasm Cytoplasm XPC Complex
	Molecular Function	Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Metal Ion Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly In Utero Embryonic Development DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair DNA Recombination Meiotic Nuclear Division Positive Regulation Of Cell Proliferation Hemopoiesis Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Homeostasis Of Number Of Cells Within A Tissue Regulation Of Cellular Response To Heat	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Spermatogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints	Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER DNA Damage Recognition in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS			Body mass index ( 20966902) Breast cancer ( 21263130) Prostate cancer ( 23023329)
Protein-Protein Interactions		63 interactors: AICDA AKTIP ANXA1 ANXA7 ASCC2 ATM ATRIP BID BLM BRCA2 BRIP1 CCNA1 CCNA2 CCNB1 CDC5L CDK1 CDK2 CPE CSNK2B DMC1 EXO5 GNB5 HAX1 HELB HGH1 HNRNPUL1 HUS1 MCM2 MCM4 MCM6 MCM7 MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RCC1 RECQL RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WRN XPA XPC	20 interactors: ADRM1 ATXN3 CALM1 DBI DEAF1 HMGB1 MLH1 MPG NGLY1 PAX3 PNMA5 PSMD4 PUF60 RPA1 TDG UBA2 UBB UBE3A XPC ZFAND5
Entrez ID		6117	5887
HPRD ID		01565	06772
Ensembl ID		ENSG00000132383	ENSG00000119318
Uniprot IDs		P27694	B7Z4W4 P54727
PDB IDs		1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH	1P1A 1PVE 1UEL
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair DNA Replication Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA-dependent DNA Replication Cellular Nitrogen Compound Metabolic Process DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Cell Cycle Checkpoint Nitrogen Compound Metabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Regulation Of Cell Cycle Response To Ionizing Radiation DNA Conformation Change Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Organelle Organization DNA Catabolic Process Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Response To Radiation Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Cell Cycle Phase Transition DNA Strand Elongation Involved In DNA Replication Cellular Response To Stimulus Response To Abiotic Stimulus DNA Strand Elongation Signal Transduction In Response To DNA Damage Cellular Response To Ionizing Radiation Cellular Macromolecule Biosynthetic Process	Cellular Macromolecule Catabolic Process Catabolic Process Cellular Response To DNA Damage Stimulus DNA Repair DNA Catabolic Process Base-excision Repair DNA Metabolic Process Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Cellular Response To Stress Response To Stress Cellular Nitrogen Compound Metabolic Process Protein Catabolic Process Mismatch Repair Cellular Metabolic Process Base-excision Repair, AP Site Formation Modification-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Mitotic DNA Integrity Checkpoint Multicellular Organismal Development Positive Regulation Of Proteolysis Heterocycle Metabolic Process Deoxyribose Phosphate Catabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Process Nucleotide-excision Repair, DNA Damage Removal Anatomical Structure Development Programmed Cell Death System Development Cell Death Death Negative Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Response To Abiotic Stimulus Deoxyribonucleotide Catabolic Process DNA Damage Checkpoint Nervous System Development G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Developmental Process Behavioral Fear Response Fear Response Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process
Tagcloud ?		200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1	a3 adoptive bioinformatic blunting dige diploid disulfide excision galactosidase hnrnpa3 hnrnpq imr90 isomerase lesser mir mirrored pdia3 permanent perturbation proteome ribonucleoprotein senescence senescent slowed synaptotagmin syncrip untranslated utrs
Tagcloud (Difference) ?		200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1	a3 adoptive bioinformatic blunting dige diploid disulfide excision galactosidase hnrnpa3 hnrnpq imr90 isomerase lesser mir mirrored pdia3 permanent perturbation proteome ribonucleoprotein senescence senescent slowed synaptotagmin syncrip untranslated utrs
Tagcloud (Intersection) ?