PDGFRL and CTSV

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		PDGFRL	CTSV
Description		platelet derived growth factor receptor like	cathepsin V
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Lysosome Lysosomal Lumen
	Molecular Function	Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Proteolysis Involved In Protein Catabolic Process
Pathways			Endosomal/Vacuolar pathway Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs			3-amino-5-phenylpentane 4-Methylpiperazin-1-Yl Carbonyl Group
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hippocampal volume in normal cognition ( 29274321) Placental abruption ( 29884306) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma parathyroid hormone levels ( 30134803) Spatial memory ( 31596458) Sphingomyelin 24:0 levels ( 31560688)
Interacting Genes		24 interacting genes: ASPH BAAT CCDC180 CTSV FANCC FBP2 HRAS MAP2K1 MAPK12 MAPK3 MBP NANS PFKM PPP2CB PPP3R2 RANGAP1 SFRP4 SMAD1 SPARCL1 TBC1D2 TGFB1 TMEM129 XPA ZNF510	13 interacting genes: APC BMPR1A BRAF BUB1 CDKN2A CTNNA1 DCC DLC1 MLH1 MLH3 PDGFRL RB1 SRC
Entrez ID		5157	1515
HPRD ID		05206	04495
Ensembl ID		ENSG00000104213	ENSG00000136943
Uniprot IDs		Q15198	B2R717 O60911
PDB IDs			1FH0 3H6S 3KFQ 7PK4 7Q8D 7Q8F 7Q8G 7Q8H 7Q8I 7Q8J 7Q8K 7Q8L 7Q8M 7Q8N 7Q8O 7Q8P 7Q8Q 7Q9H 7QFF 7QFH 7QGW 7QHJ 7QHK 7QNS 7QO2
Enriched GO Terms of Interacting Partners?		Myelination Axon Ensheathment MAPK Cascade Regulation Of Intracellular Transport Glial Cell Development Schwann Cell Development Regulation Of Cellular Localization Regulation Of Golgi Inheritance Intracellular Signaling Cassette Trachea Formation Regulation Of Intracellular Protein Transport Fructose 1,6-bisphosphate Metabolic Process ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Catalytic Activity Bergmann Glial Cell Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of ERK1 And ERK2 Cascade Chemical Homeostasis Cytosol Fructose 6-phosphate Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Cell-cell Adhesion Regulation Of Transport Regulation Of Protein Localization MAP Kinase Activity Positive Regulation Of Intracellular Protein Transport Regulation Of MiRNA Metabolic Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Homeostatic Process Negative Regulation Of Transport Regulation Of Protein Transport Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Protein Transport Animal Organ Formation Face Development Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Intracellular Signal Transduction Gland Development Positive Regulation Of Hydrolase Activity Muscle Cell Cellular Homeostasis Regulation Of Protein Localization To Synapse Lung Morphogenesis	Chiasma Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Negative Regulation Of Nervous System Development Negative Regulation Of Cell Development Negative Regulation Of Neurogenesis Negative Regulation Of Cell-matrix Adhesion Mismatch Repair Complex Regulation Of Neurogenesis Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Negative Regulation Of Kinase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Signal Transduction Negative Regulation Of Chromosome Organization Regulation Of Phosphorylation Intracellular Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Gamma-catenin Binding Regulation Of Chromosome Organization Regulation Of Chromosome Separation Negative Regulation Of Protein Kinase Activity Regulation Of Cell Development Animal Organ Morphogenesis Somatic Stem Cell Population Maintenance Caveola Regulation Of Nervous System Development Apoptotic Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell-substrate Adhesion Mismatched DNA Binding Regulation Of Kinase Activity ATP Binding Cell Junction Assembly Regulation Of Mitotic Metaphase/anaphase Transition Programmed Cell Death Cell Death Regulation Of Phosphorus Metabolic Process Odontogenesis Ruffle Membrane Negative Regulation Of Protein Phosphorylation Regulation Of Sister Chromatid Segregation Regulation Of Cell Motility ATP-dependent DNA Damage Sensor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Multicellular Organismal Process
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