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WRN and MIB1
Number of citations of the paper that reports this interaction (PubMedID
32652764
)
0
Data Source:
BioGRID
(enzymatic study)
WRN
MIB1
Description
WRN RecQ like helicase
MIB E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Centrosome
Nuclear Speck
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Plasma Membrane
Postsynaptic Density
Membrane
Cytoplasmic Vesicle
Centriolar Satellite
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
Catalytic Activity
Helicase Activity
Nuclease Activity
Exonuclease Activity
Protein Binding
ATP Binding
3'-5' Exonuclease Activity
Four-way Junction Helicase Activity
Hydrolase Activity
Isomerase Activity
ATP Hydrolysis Activity
Manganese Ion Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
Protein-containing Complex Binding
Metal Ion Binding
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
3'-flap-structured DNA Binding
Catalytic Activity, Acting On DNA
8-hydroxy-2'-deoxyguanosine DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Synthesis Involved In DNA Repair
Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
DNA Replication
DNA Repair
Base-excision Repair
Mismatch Repair
Double-strand Break Repair
DNA Recombination
DNA Damage Response
Response To Oxidative Stress
Determination Of Adult Lifespan
Cellular Response To Starvation
Response To UV-C
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Geometric Change
Regulation Of Growth Rate
Positive Regulation Of Hydrolase Activity
Telomeric D-loop Disassembly
Cellular Response To Gamma Radiation
Cellular Senescence
Replicative Senescence
T-circle Formation
Positive Regulation Of Strand Invasion
Protein Localization To Nucleolus
Blood Vessel Development
In Utero Embryonic Development
Somitogenesis
Neural Tube Formation
Heart Looping
Ubiquitin-dependent Protein Catabolic Process
Endocytosis
Notch Signaling Pathway
Heart Development
Protein Ubiquitination
Central Nervous System Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Endocytosis
Pathways
Processive synthesis on the C-strand of the telomere
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS
Chronotype (
30696823
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Daytime sleep phenotypes (
27126917
)
Exercise treadmill test traits (
17903301
)
Fasting glucose change (long-term) (
31263163
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Intelligence (MTAG) (
29326435
)
Lifespan (
25918517
)
Logical memory (delayed recall) in mild cognitive impairment (
29274321
)
Logical memory (immediate recall) in mild cognitive impairment (
29274321
)
Metabolite levels (
23823483
)
Morning person (
30696823
)
Brain morphology (MOSTest) (
32665545
)
Mean spheric corpuscular volume (
32888494
)
Myocardial infarction (
33532862
)
Severe progression in rheumatoid arthritis (
29065906
)
Interacting Genes
34 interacting genes:
ATM
ATRX
BARD1
BLM
BRCA1
CDKN2A
FEN1
H2AX
MDC1
MDM2
MIB1
PARP1
PCNA
POLB
POLD2
POLK
POLR1C
PRKAR1B
PRKDC
RAD1
RAD51
RAD52
RAD54B
RAD9A
RPA1
RPA2
SUMO1
SUMO2
TERF2
TP53
VCP
WRNIP1
XRCC5
XRCC6
17 interacting genes:
AZI2
BLM
DAB2
DAPK1
EPB41L4A
GABARAP
JAG1
RIPK4
SNX5
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2N
UBE2U
UBE2W
WRN
Entrez ID
7486
57534
HPRD ID
05212
06660
Ensembl ID
ENSG00000165392
ENSG00000101752
Uniprot IDs
Q14191
Q86YT6
PDB IDs
2AXL
2DGZ
2E1E
2E1F
2FBT
2FBV
2FBX
2FBY
2FC0
3AAF
6TYV
6YHR
7GQS
7GQT
7GQU
7XUT
8PFL
8PFO
8PFP
8YLE
4TSE
4XI6
4XI7
4XIB
8V0D
8V0E
Enriched GO Terms of Interacting Partners
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DNA Repair
DNA Damage Response
DNA Metabolic Process
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair
Nucleic Acid Metabolic Process
Damaged DNA Binding
Chromosome, Telomeric Region
Response To Radiation
DNA Recombination
Recombinational Repair
Cellular Response To Radiation
Nucleobase-containing Compound Metabolic Process
Response To Stress
Telomere Maintenance
Cellular Response To Ionizing Radiation
Telomere Organization
Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Signal Transduction In Response To DNA Damage
Response To Gamma Radiation
Macromolecule Metabolic Process
Regulation Of Cellular Response To Stress
Chromosome Organization
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
Negative Regulation Of Cell Cycle Process
Protein Localization To Chromosome
Nucleoplasm
Regulation Of Cell Cycle Process
Regulation Of DNA Repair
DNA Binding
Regulation Of Cell Cycle Phase Transition
DNA Biosynthetic Process
Site Of Double-strand Break
Enzyme Binding
Negative Regulation Of Cell Cycle Phase Transition
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Body
Regulation Of Cell Cycle
DNA Replication
Cellular Response To Gamma Radiation
Protein Localization To Organelle
PML Body
Replication Fork Processing
Protein-containing Complex
Regulation Of DNA Recombination
Negative Regulation Of Mitotic Cell Cycle
Ubiquitin Conjugating Enzyme Activity
Protein Polyubiquitination
ATP Binding
Ubiquitin-protein Transferase Activity
Nucleotide Binding
Forked DNA-dependent Helicase Activity
Positive Regulation Of Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
8-hydroxy-2'-deoxyguanosine DNA Binding
Telomeric G-quadruplex DNA Binding
Protein Ubiquitination
Regulation Of Protein Polyubiquitination
Telomeric D-loop Binding
Y-form DNA Binding
Transferase Activity
Protein K48-linked Ubiquitination
Proteolysis Involved In Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Cellular Response To Nutrient Levels
Macromolecule Catabolic Process
Protein K11-linked Ubiquitination
DNA Repair
Four-way Junction Helicase Activity
Catabolic Process
Telomere Maintenance Via Semi-conservative Replication
Post-translational Protein Modification
DNA Geometric Change
Bubble DNA Binding
Protein Monoubiquitination
Telomeric D-loop Disassembly
G-quadruplex DNA Binding
Protein Catabolic Process
TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Telomeric Loop Disassembly
T-circle Formation
3'-5' DNA Helicase Activity
TOR Signaling
DNA Metabolic Process
Negative Regulation Of TOR Signaling
Four-way Junction DNA Binding
Proteasomal Protein Catabolic Process
DNA Conformation Change
Response To Nutrient Levels
Regulation Of TORC1 Signaling
DNA Damage Response
Cellular Response To Stress
Positive Regulation Of Protein Ubiquitination
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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