WRN and WRNIP1

Number of citations of the paper that reports this interaction (PMID 11301316)
9

Data Source:
HPRD (in vitro)

		WRN	WRNIP1
Gene Name		Werner syndrome, RecQ helicase-like	Werner helicase interacting protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Centrosome MutLalpha Complex	Nucleus Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity ATP-dependent DNA Helicase Activity Helicase Activity Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATPase Activity Manganese Ion Binding Protein Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding	DNA Binding Protein Binding ATP Binding ATPase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair Replicative Cell Aging DNA Metabolic Process DNA Replication Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organismal Aging Replication Fork Processing Nucleolus To Nucleoplasm Transport DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Synthesis Involved In DNA Repair DNA Replication Regulation Of DNA-dependent DNA Replication Initiation
Pathways
Drugs
Diseases
GWAS		Exercise treadmill test traits ( 17903301)
Protein-Protein Interactions		26 interactors: ATM ATRX BLM CDKN2A FEN1 H2AFX MDC1 PARP1 PCNA POLB POLD2 POLR1C PRKAR1B PRKDC RAD51 RAD52 RAD54B RPA1 SUMO1 SUMO2 TERF2 TP53 VCP WRNIP1 XRCC5 XRCC6	8 interactors: ABL1 DDX58 PIN1 POLD1 POLD2 POLD4 TOLLIP WRN
Entrez ID		7486	56897
HPRD ID		05212	10494
Ensembl ID		ENSG00000165392	ENSG00000124535
Uniprot IDs		Q14191 Q59F09	Q96S55
PDB IDs		2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF	3VHS 3VHT
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair DNA Metabolic Process Cellular Response To Stress DNA Recombination Telomere Maintenance Response To Stress Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Replication DNA-dependent DNA Replication Base-excision Repair Mitotic Recombination Response To Ionizing Radiation Cellular Response To Stimulus DNA Conformation Change Cell Cycle Process Cell Cycle Cellular Response To Ionizing Radiation Response To Stimulus Organelle Organization Telomere Maintenance Via Telomere Lengthening DNA Duplex Unwinding DNA Geometric Change Cellular Metabolic Process Response To Radiation Mitotic Cell Cycle Regulation Of DNA Replication Homeostatic Process Telomere Maintenance Via Semi-conservative Replication Response To Abiotic Stimulus Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Recombinase Assembly DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Macromolecule Biosynthetic Process Response To X-ray DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Mitotic DNA Damage Checkpoint	Mismatch Repair Base-excision Repair Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling DNA-dependent DNA Replication DNA Biosynthetic Process Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Response To Stress Transcription-coupled Nucleotide-excision Repair DNA Repair DNA Recombination DNA Replication Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process DNA Synthesis Involved In DNA Repair Cell Cycle Homeostatic Process Cellular Response To Stimulus Cellular Homeostasis Cellular Response To Stress Mitotic Cell Cycle Innate Immune Response Negative Regulation Of Type I Interferon Production Negative Regulation Of ERK1 And ERK2 Cascade Chromosome Organization Response To Stimulus Cell Cycle Process DNA Replication Proofreading Transitional One Stage B Cell Differentiation Regulation Of Ubiquitin-protein Transferase Activity Immune Response Regulation Of Type I Interferon Production Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Defense Response Regulation Of Cytokine Production Negative Regulation Of Phospholipase C Activity Mitochondrial Depolarization Response To UV Regulation Of Cell Motility Regulation Of Growth Rate Cellular Response To Dopamine Nucleolus To Nucleoplasm Transport RIG-I Signaling Pathway
Tagcloud ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws
Tagcloud (Difference) ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws
Tagcloud (Intersection) ?