WRN and PRKAR1B

Number of citations of the paper that reports this interaction (PMID 12067711)
4

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		WRN	PRKAR1B
Gene Name		Werner syndrome, RecQ helicase-like	protein kinase, cAMP-dependent, regulatory, type I, beta
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Centrosome MutLalpha Complex	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Ciliary Base
	Molecular Function	Magnesium Ion Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity ATP-dependent DNA Helicase Activity Helicase Activity Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATPase Activity Manganese Ion Binding Protein Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding	CAMP-dependent Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair Replicative Cell Aging DNA Metabolic Process DNA Replication Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organismal Aging Replication Fork Processing Nucleolus To Nucleoplasm Transport DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis	Renal Water Homeostasis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Learning Or Memory Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS		Exercise treadmill test traits ( 17903301)
Protein-Protein Interactions		26 interactors: ATM ATRX BLM CDKN2A FEN1 H2AFX MDC1 PARP1 PCNA POLB POLD2 POLR1C PRKAR1B PRKDC RAD51 RAD52 RAD54B RPA1 SUMO1 SUMO2 TERF2 TP53 VCP WRNIP1 XRCC5 XRCC6	8 interactors: AKAP1 EGFR PPP1R9A PRKAR1A SMAD3 SMAD4 WNK1 WRN
Entrez ID		7486	5575
HPRD ID		05212	01485
Ensembl ID		ENSG00000165392	ENSG00000188191
Uniprot IDs		Q14191 Q59F09	P31321
PDB IDs		2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF	4DIN 4F9K
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair DNA Metabolic Process Cellular Response To Stress DNA Recombination Telomere Maintenance Response To Stress Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Replication DNA-dependent DNA Replication Base-excision Repair Mitotic Recombination Response To Ionizing Radiation Cellular Response To Stimulus DNA Conformation Change Cell Cycle Process Cell Cycle Cellular Response To Ionizing Radiation Response To Stimulus Organelle Organization Telomere Maintenance Via Telomere Lengthening DNA Duplex Unwinding DNA Geometric Change Cellular Metabolic Process Response To Radiation Mitotic Cell Cycle Regulation Of DNA Replication Homeostatic Process Telomere Maintenance Via Semi-conservative Replication Response To Abiotic Stimulus Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Recombinase Assembly DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Macromolecule Biosynthetic Process Response To X-ray DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Mitotic DNA Damage Checkpoint	SMAD Protein Complex Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Protein Metabolic Process Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Cell Development Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Protein Phosphorylation Mesoderm Development Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Cellular Response To Growth Factor Stimulus Gastrulation Regulation Of Catenin Import Into Nucleus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Protein Localization To Nucleus Regulation Of Protein Transport Tissue Morphogenesis Regulation Of Nucleocytoplasmic Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Regulation Of Protein Localization Multicellular Organismal Development Negative Regulation Of Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Stem Cell Differentiation Activation Of Phospholipase C Activity SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Transport Positive Regulation Of Phospholipase C Activity Neuron Development Regulation Of Cellular Protein Metabolic Process Cell Differentiation Digestive Tract Morphogenesis Response To Stress Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Developmental Process Regulation Of Protein Catabolic Process Negative Regulation Of Phosphorylation Response To Abiotic Stimulus
Tagcloud ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	ad aimed alzheimer app c9orf72 defect defects dementia dutch early especially expansions find forms frequency ftd genetic grn mapt mutation mutations netherlands none onset pathogenic percent psen1 repeat resp
Tagcloud (Difference) ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	ad aimed alzheimer app c9orf72 defect defects dementia dutch early especially expansions find forms frequency ftd genetic grn mapt mutation mutations netherlands none onset pathogenic percent psen1 repeat resp
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