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WRN and BLM
Number of citations of the paper that reports this interaction (PubMedID
11919194
)
0
Data Source:
HPRD
(in vitro, in vivo)
WRN
BLM
Description
WRN RecQ like helicase
BLM RecQ like helicase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Centrosome
Nuclear Speck
Nuclear Chromosome
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
RecQ Family Helicase-topoisomerase III Complex
Protein-containing Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
Catalytic Activity
Helicase Activity
Nuclease Activity
Exonuclease Activity
Protein Binding
ATP Binding
3'-5' Exonuclease Activity
Four-way Junction Helicase Activity
Hydrolase Activity
Isomerase Activity
ATP Hydrolysis Activity
Manganese Ion Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
Protein-containing Complex Binding
Metal Ion Binding
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
3'-flap-structured DNA Binding
Catalytic Activity, Acting On DNA
8-hydroxy-2'-deoxyguanosine DNA Binding
Nucleotide Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
P53 Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Zinc Ion Binding
Four-way Junction Helicase Activity
Hydrolase Activity
Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides
Isomerase Activity
ATP Hydrolysis Activity
Identical Protein Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
Metal Ion Binding
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
DNA/DNA Annealing Activity
Biological Process
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Synthesis Involved In DNA Repair
Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
DNA Replication
DNA Repair
Base-excision Repair
Mismatch Repair
Double-strand Break Repair
DNA Recombination
DNA Damage Response
Response To Oxidative Stress
Determination Of Adult Lifespan
Cellular Response To Starvation
Response To UV-C
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Geometric Change
Regulation Of Growth Rate
Positive Regulation Of Hydrolase Activity
Telomeric D-loop Disassembly
Cellular Response To Gamma Radiation
Cellular Senescence
Replicative Senescence
T-circle Formation
Positive Regulation Of Strand Invasion
Protein Localization To Nucleolus
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Repair
DNA Recombination
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Response To X-ray
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Geometric Change
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA Recombination
Protein Complex Oligomerization
Protein Homooligomerization
Negative Regulation Of Cell Division
Telomeric D-loop Disassembly
Resolution Of DNA Recombination Intermediates
Cellular Response To Ionizing Radiation
Cellular Response To Hydroxyurea
Cellular Response To Camptothecin
T-circle Formation
Pathways
Processive synthesis on the C-strand of the telomere
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Processive synthesis on the C-strand of the telomere
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Chronotype (
30696823
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Daytime sleep phenotypes (
27126917
)
Exercise treadmill test traits (
17903301
)
Fasting glucose change (long-term) (
31263163
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Intelligence (MTAG) (
29326435
)
Lifespan (
25918517
)
Logical memory (delayed recall) in mild cognitive impairment (
29274321
)
Logical memory (immediate recall) in mild cognitive impairment (
29274321
)
Metabolite levels (
23823483
)
Morning person (
30696823
)
Coronary artery disease (
32469254
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
34 interacting genes:
ATM
ATRX
BARD1
BLM
BRCA1
CDKN2A
FEN1
H2AX
MDC1
MDM2
MIB1
PARP1
PCNA
POLB
POLD2
POLK
POLR1C
PRKAR1B
PRKDC
RAD1
RAD51
RAD52
RAD54B
RAD9A
RPA1
RPA2
SUMO1
SUMO2
TERF2
TP53
VCP
WRNIP1
XRCC5
XRCC6
39 interacting genes:
ATR
ATRX
BRIP1
CASP3
CHAF1A
CHEK1
DNA2
EXO1
FANCD2
FBXW7
FEN1
JUN
MCRS1
MIB1
MLH1
MX1
NEK11
PSMD3
RAD51
RAD51D
RNF4
RNF8
RPA1
SMC1A
SPIDR
SUMO1
SUMO2
SUMO3
SYN1
TERF1
TERF2
TOP3A
TP53
TP53BP1
TRIM49
UBE2I
UPF2
USP37
WRN
Entrez ID
7486
641
HPRD ID
05212
05211
Ensembl ID
ENSG00000165392
ENSG00000197299
Uniprot IDs
Q14191
B7ZKN7
H0YNU5
P54132
PDB IDs
2AXL
2DGZ
2E1E
2E1F
2FBT
2FBV
2FBX
2FBY
2FC0
3AAF
6TYV
6YHR
7GQS
7GQT
7GQU
7XUT
8PFL
8PFO
8PFP
8YLE
2KV2
2MH9
2RRD
3WE2
3WE3
4CDG
4CGZ
4O3M
5LUP
5MK5
5U6K
7AUC
7AUD
7XUW
7XV0
Enriched GO Terms of Interacting Partners
?
DNA Repair
DNA Damage Response
DNA Metabolic Process
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair
Nucleic Acid Metabolic Process
Damaged DNA Binding
Chromosome, Telomeric Region
Response To Radiation
DNA Recombination
Recombinational Repair
Cellular Response To Radiation
Nucleobase-containing Compound Metabolic Process
Response To Stress
Telomere Maintenance
Cellular Response To Ionizing Radiation
Telomere Organization
Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Signal Transduction In Response To DNA Damage
Response To Gamma Radiation
Macromolecule Metabolic Process
Regulation Of Cellular Response To Stress
Chromosome Organization
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
Negative Regulation Of Cell Cycle Process
Protein Localization To Chromosome
Nucleoplasm
Regulation Of Cell Cycle Process
Regulation Of DNA Repair
DNA Binding
Regulation Of Cell Cycle Phase Transition
DNA Biosynthetic Process
Site Of Double-strand Break
Enzyme Binding
Negative Regulation Of Cell Cycle Phase Transition
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Body
Regulation Of Cell Cycle
DNA Replication
Cellular Response To Gamma Radiation
Protein Localization To Organelle
PML Body
Replication Fork Processing
Protein-containing Complex
Regulation Of DNA Recombination
Negative Regulation Of Mitotic Cell Cycle
DNA Damage Response
DNA Repair
DNA Metabolic Process
Chromosome Organization
Cellular Response To Stress
Double-strand Break Repair
Macromolecule Metabolic Process
Chromosome, Telomeric Region
PML Body
Nucleic Acid Metabolic Process
Nucleoplasm
Response To Stress
Telomere Maintenance
Regulation Of DNA Metabolic Process
DNA Recombination
Telomere Organization
Regulation Of Cell Cycle
Chromosome
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle
Nucleus
Negative Regulation Of Cell Cycle Process
Positive Regulation Of DNA Metabolic Process
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Replication Fork
Signal Transduction In Response To DNA Damage
Response To Radiation
Regulation Of DNA Replication
Interstrand Cross-link Repair
Nuclear Body
Chromosome Organization Involved In Meiotic Cell Cycle
DNA Damage Checkpoint Signaling
Organelle Organization
Nuclear Chromosome
T-circle Formation
Cellular Response To Ionizing Radiation
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Replicative Senescence
Regulation Of DNA Recombination
Recombinational Repair
Replication Fork Processing
DNA Replication
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of DNA Repair
Regulation Of Chromosome Organization
Condensed Nuclear Chromosome
Chromatin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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