GET1 and SCN3A

Data Source: HiPPIP (Novel)

		GET1	SCN3A
Name		guided entry of tail-anchored proteins factor 1	sodium voltage-gated channel alpha subunit 3
Structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex	Voltage-gated Sodium Channel Complex Plasma Membrane Basal Plasma Membrane Membrane Sarcoplasm Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding Protein-membrane Adaptor Activity	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane	Action Potential Monoatomic Ion Transport Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Behavioral Response To Pain Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		None	Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Lacosamide Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
GWAS		No GWAS studies recorded	Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Epilepsy ( 30531953 ) Focal epilepsy ( 30531953 ) Generalized epilepsy ( 30531953 ) Metabolite levels ( 23823483 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 ) Parkinson's disease ( 28892059 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Novel Interactors		6 novel interactors: BOC GATD3 PDXK SCN3A SLC4A2 TRAPPC10	1 novel interactors: GET1
Interacting Genes		28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42	5 interacting genes: CNTN1 LRP1 LRP2 LRP8 PRKCG
Entrez ID		7485	6328
HPRD ID		04224	01671
Ensembl ID		ENSG00000182093	ENSG00000153253
Uniprot IDs		O00258	A0A590UJH3 A0A994J5P2 Q9C007 Q9NY46
PDB IDs		6SO5 8CQZ 8CR1 8CR2	7W77 7W7F
GO Terms Enriched among Interactors		Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex	Low-density Lipoprotein Particle Receptor Activity Cargo Receptor Activity Positive Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Terpenoid Metabolic Process Isoprenoid Metabolic Process Regulation Of Lysosomal Protein Catabolic Process Apolipoprotein Binding Transcytosis Receptor Complex Amyloid-beta Clearance Artery Morphogenesis Regulation Of Protein Catabolic Process Axon Positive Regulation Of Transcytosis Endocytosis Transport Across Blood-brain Barrier Clathrin-coated Pit Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Ammon Gyrus Development Amyloid-beta Binding Dendrite Blood Vessel Morphogenesis Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis System Process Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Reelin Receptor Activity Calcium Ion Binding Import Into Cell Lipoprotein Particle Receptor Binding Folate Transmembrane Transport Sensory Perception Of Sound Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Mismatch Repair GET Complex Sensory Perception Of Mechanical Stimulus Positive Regulation Of Neuron Projection Development Astrocyte Activation Involved In Immune Response Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Mismatch Repair Very-low-density Lipoprotein Particle Receptor Activity Receptor-mediated Endocytosis Response To Psychosocial Stress Anatomical Structure Formation Involved In Morphogenesis