SCN3A and GET1

Data Source: HiPPIP (Novel)

		SCN3A	GET1
Name		sodium voltage-gated channel alpha subunit 3	guided entry of tail-anchored proteins factor 1
Structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Basal Plasma Membrane Membrane Sarcoplasm Monoatomic Ion Channel Complex	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity	Protein Binding Protein-membrane Adaptor Activity
	Biological Process	Action Potential Monoatomic Ion Transport Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Behavioral Response To Pain Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Lacosamide Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil	None
GWAS		Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Epilepsy ( 30531953 ) Focal epilepsy ( 30531953 ) Generalized epilepsy ( 30531953 ) Metabolite levels ( 23823483 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 ) Parkinson's disease ( 28892059 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: GET1	6 novel interactors: BOC GATD3 PDXK SCN3A SLC4A2 TRAPPC10
Interacting Genes		5 interacting genes: CNTN1 LRP1 LRP2 LRP8 PRKCG	28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42
Entrez ID		6328	7485
HPRD ID		01671	04224
Ensembl ID		ENSG00000153253	ENSG00000182093
Uniprot IDs		A0A590UJH3 A0A994J5P2 Q9C007 Q9NY46	O00258
PDB IDs		7W77 7W7F	6SO5 8CQZ 8CR1 8CR2
GO Terms Enriched among Interactors		Low-density Lipoprotein Particle Receptor Activity Cargo Receptor Activity Positive Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Terpenoid Metabolic Process Isoprenoid Metabolic Process Regulation Of Lysosomal Protein Catabolic Process Apolipoprotein Binding Transcytosis Receptor Complex Amyloid-beta Clearance Artery Morphogenesis Regulation Of Protein Catabolic Process Axon Positive Regulation Of Transcytosis Endocytosis Transport Across Blood-brain Barrier Clathrin-coated Pit Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Ammon Gyrus Development Amyloid-beta Binding Dendrite Blood Vessel Morphogenesis Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis System Process Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Reelin Receptor Activity Calcium Ion Binding Import Into Cell Lipoprotein Particle Receptor Binding Folate Transmembrane Transport Sensory Perception Of Sound Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Mismatch Repair GET Complex Sensory Perception Of Mechanical Stimulus Positive Regulation Of Neuron Projection Development Astrocyte Activation Involved In Immune Response Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Mismatch Repair Very-low-density Lipoprotein Particle Receptor Activity Receptor-mediated Endocytosis Response To Psychosocial Stress Anatomical Structure Formation Involved In Morphogenesis	Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex