GET1 and SPTSSA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GET1	SPTSSA
Description		guided entry of tail-anchored proteins factor 1	serine palmitoyltransferase small subunit A
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex
	Molecular Function	Protein Binding Protein-membrane Adaptor Activity	Serine C-palmitoyltransferase Activity Protein Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane	Lipid Metabolic Process Sphingolipid Metabolic Process Intracellular Protein Localization Sphingolipid Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Intraocular pressure ( 29785010 31959993)
Interacting Genes		28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42	8 interacting genes: CYSRT1 GET1 GLP1R HERPUD2 RHBDL1 TMEM31 TUBB3 VKORC1
Entrez ID		7485	171546
HPRD ID		04224	16610
Ensembl ID		ENSG00000182093	ENSG00000165389
Uniprot IDs		O00258	Q969W0
PDB IDs		6SO5 8CQZ 8CR1 8CR2	6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2
Enriched GO Terms of Interacting Partners?		Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex
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