SCN3A and LRP8

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
BioGRID (two hybrid)

		SCN3A	LRP8
Gene Name		sodium channel, voltage gated, type III alpha subunit	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Cytoplasm Plasma Membrane	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex
	Molecular Function	Voltage-gated Sodium Channel Activity	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Reelin Receptor Activity
	Biological Process	Sodium Ion Transport Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Negative Regulation Of Transcription From RNA Polymerase II Promoter Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Signal Transduction Blood Coagulation Phototransduction, Visible Light Cytokine-mediated Signaling Pathway Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions	Visual phototransduction Platelet homeostasis Platelet sensitization by LDL Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Body mass index (interaction) ( 23192594)
Protein-Protein Interactions		4 interactors: LRP1 LRP2 LRP8 PRKCG	19 interactors: ANAPC10 APBA2 APOE APOH CLU DAB1 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP
Entrez ID		6328	7804
HPRD ID		01671	04002
Ensembl ID		ENSG00000153253
Uniprot IDs		Q9C007 Q9NY46	Q14114
PDB IDs			3A7Q
Enriched GO Terms of Interacting Partners?		Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Response To Light Stimulus Receptor-mediated Endocytosis Response To Radiation Detection Of Stimulus Regulation Of Phospholipase Activity Endocytosis Positive Regulation Of Mismatch Repair Ammon Gyrus Development Beta-amyloid Clearance Cellular Lipid Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Mismatch Repair Response To Abiotic Stimulus Negative Regulation Of Neuron Death Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Neuron Apoptotic Process Lipid Metabolic Process Steroid Metabolic Process Regulation Of Neuron Death Vesicle-mediated Transport System Development Reelin-mediated Signaling Pathway Alcohol Metabolic Process Multicellular Organismal Development Response To External Stimulus Blood Coagulation Anatomical Structure Development Hemostasis Regulation Of Phospholipase A2 Activity Forebrain Development Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Chemosensory Behavior Vitamin D Metabolic Process Signal Transduction Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Cholesterol Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Developmental Process Protein Metabolic Process Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux	Regulation Of Beta-amyloid Clearance Membrane Depolarization Regulation Of Signaling Receptor Clustering Regulation Of Cellular Protein Metabolic Process Regulation Of Membrane Potential Positive Regulation Of Catalytic Activity Regulation Of Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Ion Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Catalytic Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Ion Transmembrane Transport Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Postsynaptic Membrane Organization Regulation Of Kinase Activity Lateral Motor Column Neuron Migration Regulation Of Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Cell-cell Signaling Positive Regulation Of Protein Modification Process Social Behavior Learning Dendrite Development Regulation Of Ion Transmembrane Transporter Activity Behavior Positive Regulation Of Membrane Potential Regulation Of Transmembrane Transporter Activity Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Synaptic Plasticity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering
Tagcloud ?		arrhythmias bjip black buthotus caught contractility desert hottentotta inotropic judean nav1 proarrhythmic prolong provoke provoked repolarization rodent safely scorpion scorpions sedated slices sodium tetrodotoxin thalamic transients venom venoms ventricular	aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Difference) ?		arrhythmias bjip black buthotus caught contractility desert hottentotta inotropic judean nav1 proarrhythmic prolong provoke provoked repolarization rodent safely scorpion scorpions sedated slices sodium tetrodotoxin thalamic transients venom venoms ventricular	aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Intersection) ?