GET1 and TECR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GET1	TECR
Description		guided entry of tail-anchored proteins factor 1	trans-2,3-enoyl-CoA reductase
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Protein-membrane Adaptor Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Very-long-chain Fatty Acyl-CoA Dehydrogenase Activity Very-long-chain Enoyl-CoA Reductase Activity
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Fatty Acid Elongation Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42	33 interacting genes: AQP6 ARL13B CD79A CLDN5 CRB3 CREB3 CREB3L1 ELOVL4 ERGIC3 FAM209A FBXO7 FKBP7 GET1 GOLT1A HACD1 JAGN1 MMGT1 MUC1 NOS3 PAXIP1 PGRMC2 PTEN RETREG3 SAR1A SLC10A6 SLC18A1 SLC35H1 SLC71A2 SLC7A14 STING1 STOM TFAM VMA21
Entrez ID		7485	9524
HPRD ID		04224	17076
Ensembl ID		ENSG00000182093	ENSG00000099797
Uniprot IDs		O00258	B3KSQ1 B4DR74 Q9NZ01
PDB IDs		6SO5 8CQZ 8CR1 8CR2	2DZJ
Enriched GO Terms of Interacting Partners?		Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Schmidt-Lanterman Incisure Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Protein Binding Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Intrinsic Apoptotic Signaling Pathway
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