GET1 and PDXK

		GET1	PDXK
Description		guided entry of tail-anchored proteins factor 1	pyridoxal kinase
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Secretory Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding Protein-membrane Adaptor Activity	Nucleotide Binding Magnesium Ion Binding ATP Binding Zinc Ion Binding Pyridoxal Kinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Pyridoxal Phosphate Binding Potassium Ion Binding Sodium Ion Binding Lithium Ion Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane	Pyridoxal 5'-phosphate Salvage Pyridoxal Metabolic Process Pyridoxamine Metabolic Process Pyridoxal Phosphate Metabolic Process
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Neutrophil degranulation Vitamin B6 activation to pyridoxal phosphate
Drugs			Pyridoxal Pyridoxine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate O6-(R)-ROSCOVITINE, R-2-(6-BENZYLOXY-9-ISOPROPYL-9H-PURIN-2-YLAMINO)-BUTAN-1-OL (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol
Diseases
GWAS			Blood protein levels ( 30072576) Refractive error ( 32231278) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42	2 interacting genes: BARD1 YWHAQ
Entrez ID		7485	8566
HPRD ID		04224	01526
Ensembl ID		ENSG00000182093	ENSG00000160209
Uniprot IDs		O00258	F2Z2Y4 O00764 V9HWC3
PDB IDs		6SO5 8CQZ 8CR1 8CR2	2AJP 2F7K 2YXT 2YXU 3FHX 3FHY 3KEU 4EN4 4EOH 8WR2
Enriched GO Terms of Interacting Partners?		Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex GET Complex Positive Regulation Of Interleukin-6-mediated Signaling Pathway Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process BRCA1-A Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex Negative Regulation Of Protein Export From Nucleus BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Protein Targeting Otic Vesicle Development Ripoptosome Positive Regulation Of MiRNA Processing JUN Kinase Kinase Kinase Activity Necroptotic Signaling Pathway Death-inducing Signaling Complex Peptidyl-serine Autophosphorylation Positive Regulation Of Necroptotic Process Regulation Of MRNA 3'-end Processing Positive Regulation Of Programmed Necrotic Cell Death Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Transport Regulation Of Phosphorylation DNA Strand Resection Involved In Replication Fork Processing Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Macrophage Differentiation Regulation Of MiRNA Processing Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Necroptotic Process Regulation Of Regulatory NcRNA Processing Death Receptor Binding Intracellular Signal Transduction Negative Regulation Of Necroptotic Process Positive Regulation Of Execution Phase Of Apoptosis Programmed Necrotic Cell Death Negative Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Programmed Cell Death Protein K6-linked Ubiquitination Regulation Of Phosphorus Metabolic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of Apoptotic Process Regulation Of DNA Damage Checkpoint Protein Targeting To ER
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