SCN3A and PRKCG

Number of citations: 46 (PubMedID 20395553)
Data Source: BioGRID (pull down)

		SCN3A	PRKCG
Name		sodium voltage-gated channel alpha subunit 3	protein kinase C gamma
Structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Basal Plasma Membrane Membrane Sarcoplasm Monoatomic Ion Channel Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Cell Projection Neuron Projection Calyx Of Held Synapse Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Action Potential Monoatomic Ion Transport Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Behavioral Response To Pain Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Response To Toxic Substance Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Pain Rhythmic Process Regulation Of Phagocytosis Long-term Synaptic Potentiation Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Via Neuropeptide Negative Regulation Of Proteasomal Protein Catabolic Process Response To Angiotensin Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste	Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Lacosamide Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil	Tamoxifen Staurosporine Dequalinium Benzoyl peroxide Fostamatinib
Diseases		None	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Epilepsy ( 30531953 ) Focal epilepsy ( 30531953 ) Generalized epilepsy ( 30531953 ) Metabolite levels ( 23823483 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 ) Parkinson's disease ( 28892059 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: GET1	2 novel interactors: LAIR1 PABPC4
Interacting Genes		5 interacting genes: CNTN1 LRP1 LRP2 LRP8 PRKCG	64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 RIGI SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG
Entrez ID		6328	5582
HPRD ID		01671	01502
Ensembl ID		ENSG00000153253	ENSG00000126583
Uniprot IDs		A0A590UJH3 A0A994J5P2 Q9C007 Q9NY46	A0A804HIU5 B2R5T1 B7Z3W6 P05129
PDB IDs		7W77 7W7F	2E73 2UZP
GO Terms Enriched among Interactors		Low-density Lipoprotein Particle Receptor Activity Cargo Receptor Activity Positive Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Terpenoid Metabolic Process Isoprenoid Metabolic Process Regulation Of Lysosomal Protein Catabolic Process Apolipoprotein Binding Transcytosis Receptor Complex Amyloid-beta Clearance Artery Morphogenesis Regulation Of Protein Catabolic Process Axon Positive Regulation Of Transcytosis Endocytosis Transport Across Blood-brain Barrier Clathrin-coated Pit Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Ammon Gyrus Development Amyloid-beta Binding Dendrite Blood Vessel Morphogenesis Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis System Process Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Reelin Receptor Activity Calcium Ion Binding Import Into Cell Lipoprotein Particle Receptor Binding Folate Transmembrane Transport Sensory Perception Of Sound Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Mismatch Repair GET Complex Sensory Perception Of Mechanical Stimulus Positive Regulation Of Neuron Projection Development Astrocyte Activation Involved In Immune Response Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Mismatch Repair Very-low-density Lipoprotein Particle Receptor Activity Receptor-mediated Endocytosis Response To Psychosocial Stress Anatomical Structure Formation Involved In Morphogenesis	Cytoplasm Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Postsynapse Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Cytosol Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Cell-cell Signaling Regulation Of Transport Signaling Cell Junction Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Communication Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Protein Localization Postsynaptic Membrane Regulation Of Biological Quality Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Focal Adhesion Regulation Of Signal Transduction Neuron Projection Cell Junction Assembly PAR Polarity Complex Protein Kinase C Binding Protein Kinase Binding Regulation Of System Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Glutamate Receptor Activity Glutamate Binding Developmental Process Positive Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Regulation Of Neuronal Synaptic Plasticity Anchoring Junction Monoatomic Ion Channel Activity Positive Regulation Of Cellular Component Organization Regulation Of Presynaptic Membrane Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity