ITK and BMX

Number of citations of the paper that reports this interaction (PMID 12573241)
7

Data Source:
HPRD (in vitro)

		ITK	BMX
Gene Name		IL2-inducible T-cell kinase	BMX non-receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Receptor Binding Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Interferon-gamma Production Interleukin-4 Production Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway T Cell Activation Regulation Of Cell Proliferation Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Adaptive Immune Response Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mesoderm Development Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response Protein Autophosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		TCR signaling Generation of second messenger molecules Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System	Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs		Staurosporine Pazopanib
Diseases
GWAS		Personality dimensions ( 21368711)
Protein-Protein Interactions		29 interactors: BLNK BMX BTK CBL CD28 DOK1 ERBB2 ERBB3 FASLG FGFR1 FYN GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 PLCG1 PLCG2 PPIA SH2D2A SMAD4 SOCS1 SPRR2A SRC TGFBR1 WAS	23 interactors: APP BCAR1 BTK C12orf45 CASP3 CAV1 EGFR ERBB2 FBXO25 ITK KDR PAK1 PTK2 PTPN21 RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B
Entrez ID		3702	660
HPRD ID		01746	02111
Ensembl ID		ENSG00000113263	ENSG00000102010
Uniprot IDs		Q08881	P51813
PDB IDs		1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO	2EKX 2YS2 3SXR 3SXS
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Immune Response Positive Regulation Of Signal Transduction Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Signal Transduction Antigen Receptor-mediated Signaling Pathway Defense Response Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Signaling ERBB Signaling Pathway Cell Communication T Cell Receptor Signaling Pathway Intracellular Signal Transduction Cell Activation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Wound Healing Regulation Of Immune System Process Cellular Response To Stimulus Response To Wounding Cellular Response To Growth Factor Stimulus Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Stress Neurotrophin Signaling Pathway Positive Regulation Of Immune Response Regulation Of Signal Transduction Response To Organic Substance Blood Coagulation Hemostasis Positive Regulation Of Intracellular Signal Transduction Platelet Activation Regulation Of Signaling Positive Regulation Of Immune System Process Phosphatidylinositol-mediated Signaling Cell Differentiation Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Organic Substance	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Immune System Process Peptidyl-tyrosine Phosphorylation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Intracellular Signal Transduction Response To Organic Substance Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Response To Growth Factor Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Response To Organonitrogen Compound Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Signaling Pathway Response To Wounding Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Innate Immune Response Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Neurotrophin Signaling Pathway Wound Healing Regulation Of Cell Death Signal Transduction Peptidyl-amino Acid Modification Response To Hormone Response To Peptide Hormone Immune Response Protein Phosphorylation Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Signaling Response To Peptide Cell Communication Growth Hormone Receptor Signaling Pathway Regulation Of Protein Kinase Activity
Tagcloud ?		adrenergic ark bind btk coincides computer databases defects difficult difficulty domains find homologues homology hypothesis irs overcome ph pleckstrin program programs simple substrate teca termini transduction trimeric unrecognized widely	additive androgen attenuation btk chemo confer correlates ctn06 docetaxel dtx dual etk grades healing herein immortalized impeded independence killing never pc3 perception prostate raf sensitizer tec vegfr wound xenograft
Tagcloud (Difference) ?		adrenergic ark bind coincides computer databases defects difficult difficulty domains find homologues homology hypothesis irs overcome ph pleckstrin program programs simple substrate teca termini transduction trimeric unrecognized widely	additive androgen attenuation chemo confer correlates ctn06 docetaxel dtx dual etk grades healing herein immortalized impeded independence killing never pc3 perception prostate raf sensitizer tec vegfr wound xenograft
Tagcloud (Intersection) ?		btk