ITK and BLNK

Number of citations of the paper that reports this interaction (PMID 10556826)
52

Data Source:
HPRD (in vitro)

		ITK	BLNK
Gene Name		IL2-inducible T-cell kinase	B-cell linker
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Intracellular Cytosol Plasma Membrane
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Interferon-gamma Production Interleukin-4 Production Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway T Cell Activation Regulation Of Cell Proliferation Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction
Pathways		TCR signaling Generation of second messenger molecules Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by Interleukins Regulation of signaling by CBL Cytokine Signaling in Immune system Interleukin-3, 5 and GM-CSF signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs		Staurosporine Pazopanib
Diseases
GWAS		Personality dimensions ( 21368711)
Protein-Protein Interactions		29 interactors: BLNK BMX BTK CBL CD28 DOK1 ERBB2 ERBB3 FASLG FGFR1 FYN GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 PLCG1 PLCG2 PPIA SH2D2A SMAD4 SOCS1 SPRR2A SRC TGFBR1 WAS	20 interactors: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1
Entrez ID		3702	29760
HPRD ID		01746	05153
Ensembl ID		ENSG00000113263	ENSG00000095585
Uniprot IDs		Q08881	Q2MD54 Q2MD59 Q8WV28
PDB IDs		1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Immune Response Positive Regulation Of Signal Transduction Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Signal Transduction Antigen Receptor-mediated Signaling Pathway Defense Response Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Signaling ERBB Signaling Pathway Cell Communication T Cell Receptor Signaling Pathway Intracellular Signal Transduction Cell Activation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Wound Healing Regulation Of Immune System Process Cellular Response To Stimulus Response To Wounding Cellular Response To Growth Factor Stimulus Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Stress Neurotrophin Signaling Pathway Positive Regulation Of Immune Response Regulation Of Signal Transduction Response To Organic Substance Blood Coagulation Hemostasis Positive Regulation Of Intracellular Signal Transduction Platelet Activation Regulation Of Signaling Positive Regulation Of Immune System Process Phosphatidylinositol-mediated Signaling Cell Differentiation Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Organic Substance	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Activation Immune Response Immune System Process Signal Transduction Regulation Of Lymphocyte Activation Signaling Cell Communication Regulation Of T Cell Activation Regulation Of Cell Activation Leukocyte Activation Defense Response B Cell Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Response To Stimulus Lymphocyte Activation Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Platelet Activation Positive Regulation Of Cell Adhesion Chemotaxis Wound Healing Positive Regulation Of T Cell Activation Locomotion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Response To Stress
Tagcloud ?		adrenergic ark bind btk coincides computer databases defects difficult difficulty domains find homologues homology hypothesis irs overcome ph pleckstrin program programs simple substrate teca termini transduction trimeric unrecognized widely	bcr btk card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp signalling syk tonic underscored
Tagcloud (Difference) ?		adrenergic ark bind coincides computer databases defects difficult difficulty domains find homologues homology hypothesis irs overcome ph pleckstrin program programs simple substrate teca termini transduction trimeric unrecognized widely	bcr card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp signalling syk tonic underscored
Tagcloud (Intersection) ?		btk