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ITK and PLCG2
Number of citations of the paper that reports this interaction (PubMedID
15184383
)
0
Data Source:
HPRD
(in vitro)
ITK
PLCG2
Description
IL2 inducible T cell kinase
phospholipase C gamma 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Ruffle Membrane
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Intracellular Vesicle
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Phosphotyrosine Residue Binding
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
Phospholipase C Activity
Protein Binding
Phosphoric Diester Hydrolase Activity
Hydrolase Activity
Protein Kinase Binding
Scaffold Protein Binding
Phosphorylation-dependent Protein Binding
Protein Tyrosine Kinase Binding
Biological Process
Positive Regulation Of Cytokine Production
NK T Cell Differentiation
Adaptive Immune Response
Immune System Process
Cellular Defense Response
Signal Transduction
Intracellular Signal Transduction
T Cell Activation
Gamma-delta T Cell Activation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Cell Activation
Response To Yeast
Positive Regulation Of Receptor Internalization
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Macrophage Activation Involved In Immune Response
Follicular B Cell Differentiation
Positive Regulation Of Dendritic Cell Cytokine Production
Lipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Signal Transduction
Phospholipid Catabolic Process
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Programmed Cell Death
Lipid Catabolic Process
Wnt Signaling Pathway
Regulation Of Lipid Metabolic Process
Calcium-mediated Signaling
Platelet Activation
B Cell Differentiation
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Inositol Trisphosphate Biosynthetic Process
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
B Cell Activation
Negative Regulation Of Programmed Cell Death
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Phosphatidylinositol Metabolic Process
Phosphatidylinositol-mediated Signaling
Response To Axon Injury
Positive Regulation Of Calcium-mediated Signaling
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Sequestering Of Calcium Ion
Positive Regulation Of Phagocytosis, Engulfment
Positive Regulation Of Macrophage Cytokine Production
Antifungal Innate Immune Response
Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Calcium Ion
Cellular Response To Lipid
Positive Regulation Of Neuroinflammatory Response
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Lectin
Pathways
Generation of second messenger molecules
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
GPVI-mediated activation cascade
Toll Like Receptor 4 (TLR4) Cascade
Synthesis of IP3 and IP4 in the cytosol
Generation of second messenger molecules
Role of phospholipids in phagocytosis
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Dectin-2 family
Erythropoietin activates Phospholipase C gamma (PLCG)
FCGR3A-mediated IL10 synthesis
Potential therapeutics for SARS
Signaling by CSF1 (M-CSF) in myeloid cells
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Staurosporine
Pazopanib
Fostamatinib
Zanubrutinib
Diseases
GWAS
Asthma (
31959851
34103634
)
Daytime sleep phenotypes (
27126917
)
Eosinophil count (
32888494
)
Heel bone mineral density (
30598549
)
Personality traits in bipolar disorder (
21368711
)
T-Cell Immunoglobulin and Mucin domain 1 levels (
32460577
)
Alzheimer's disease (
34099642
)
Alzheimer's disease (late onset) (
28714976
)
Blood protein levels (
30072576
)
Breast cancer (menopausal hormone therapy interaction) (
24080446
)
Ceramide levels (C24:0) (
32489964
)
Chronic widespread musculoskeletal pain (
33331911
)
Coronary artery disease (
33020668
29212778
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Height (
28552196
)
Inflammatory bowel disease (
28067908
)
Mean platelet volume (
27863252
32888494
)
Metabolite levels (
23823483
)
Myocardial infarction (
33532862
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Serum metabolite levels (
33031748
)
Takayasu arteritis (
33308445
)
Ulcerative colitis (
28067908
)
Upper eyelid morphology (
29921221
)
Venous thromboembolism (
31420334
31676865
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
34 interacting genes:
BLNK
BMX
BTK
CBL
CD28
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FYN
GAB1
GRB2
HNRNPK
IKBKG
KHDRBS1
KPNA2
LAT
LCK
LCP2
MET
PLCG1
PLCG2
PPIA
SH2D2A
SMAD4
SMURF1
SOCS1
SPRR2A
SRC
TGFBR1
WAS
56 interacting genes:
AR
ASB9
BLK
BLNK
BTK
CBLB
CD19
DAPP1
EGFR
ELK1
EPOR
EPYC
ERBB2
ERBB3
ERBB4
ESD
FCER1G
FLT1
FYN
GAB1
GAB2
GABPB2
HCK
HSPD1
IRS1
ISL1
ITK
JAK1
JAK2
KCTD17
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LHX8
LIME1
LYN
MET
NPM1
PRKD1
PTPN6
PTTG1
RALBP1
RTL10
SETD9
SH3BP2
SHC1
SYK
TEC
TP53
TWIST2
ZKSCAN7
ZNF512B
Entrez ID
3702
5336
HPRD ID
01746
02570
Ensembl ID
ENSG00000113263
ENSG00000197943
Uniprot IDs
Q08881
P16885
PDB IDs
1SM2
1SNU
1SNX
2E6I
2LMJ
2YUQ
3MIY
3MJ1
3MJ2
3QGW
3QGY
3T9T
3V5J
3V5L
3V8T
3V8W
4HCT
4HCU
4HCV
4KIO
4L7S
4M0Y
4M0Z
4M12
4M13
4M14
4M15
4MF0
4MF1
4PP9
4PPA
4PPB
4PPC
4PQN
4QD6
4RFM
2K2J
2W2W
2W2X
8JQG
8JQH
8JQI
8T7C
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
T Cell Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Cell Activation
Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Positive Regulation Of Signal Transduction
Phospholipase Binding
ERBB Signaling Pathway
Regulation Of Apoptotic Process
Immune System Process
Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Protein Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Immune Response
Intracellular Signaling Cassette
Leukocyte Activation
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Kinase Activity
Regulation Of Immune Response
Regulation Of MAPK Cascade
Membrane Raft
Positive Regulation Of Immune System Process
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Phosphorylation
Negative Regulation Of Programmed Cell Death
ERBB2 Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Immune Response-regulating Signaling Pathway
Immune Response-activating Signaling Pathway
B Cell Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Activation Of Immune Response
Protein Kinase Activity
Signal Transduction
Lymphocyte Activation
Leukocyte Activation
Protein Phosphorylation
Positive Regulation Of Immune Response
Intracellular Signal Transduction
Kinase Activity
Phosphorylation
SH2 Domain Binding
Cell Activation
Positive Regulation Of Immune System Process
T Cell Receptor Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Membrane Raft
Cell Differentiation
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Immune System Process
Positive Regulation Of Cell Population Proliferation
Fc Receptor Signaling Pathway
T Cell Activation
Cellular Developmental Process
Immune Effector Process
Leukocyte Proliferation
Regulation Of Immune System Process
Positive Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
ATP Binding
Positive Regulation Of MAPK Cascade
Adaptive Immune Response
Protein Autophosphorylation
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