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ITK and SOCS1
Number of citations of the paper that reports this interaction (PubMedID
10022833
)
84
Data Source:
HPRD
(in vitro)
ITK
SOCS1
Description
IL2 inducible T cell kinase
suppressor of cytokine signaling 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoplasmic Vesicle
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Kinase Inhibitor Activity
Cytokine Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Kinase Inhibitor Activity
Protein Kinase Binding
Biological Process
Positive Regulation Of Cytokine Production
NK T Cell Differentiation
Adaptive Immune Response
Immune System Process
Cellular Defense Response
Signal Transduction
Intracellular Signal Transduction
T Cell Activation
Gamma-delta T Cell Activation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of Cytokine Production
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Signal Transduction
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Macrophage Differentiation
Developmental Process
Intracellular Signal Transduction
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation
Fat Cell Differentiation
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Cellular Response To Amino Acid Stimulus
Pathways
Generation of second messenger molecules
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Interleukin-7 signaling
Regulation of KIT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Interferon alpha/beta signaling
Regulation of IFNA/IFNB signaling
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Staurosporine
Pazopanib
Fostamatinib
Zanubrutinib
Diseases
GWAS
Asthma (
31959851
34103634
)
Daytime sleep phenotypes (
27126917
)
Eosinophil count (
32888494
)
Heel bone mineral density (
30598549
)
Personality traits in bipolar disorder (
21368711
)
T-Cell Immunoglobulin and Mucin domain 1 levels (
32460577
)
Allergy (
27182965
)
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
29273806
)
Bulimia nervosa (
23568457
)
Celiac disease (
20190752
)
Crohn's disease (
28067908
)
Crohn's disease and psoriasis (
22482804
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Inflammatory bowel disease (
23128233
28067908
)
Multiple sclerosis (
31604244
)
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Psoriasis (
23143594
)
Psoriasis vulgaris (
26626624
)
Systemic lupus erythematosus (
27399966
26502338
)
Interacting Genes
34 interacting genes:
BLNK
BMX
BTK
CBL
CD28
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FYN
GAB1
GRB2
HNRNPK
IKBKG
KHDRBS1
KPNA2
LAT
LCK
LCP2
MET
PLCG1
PLCG2
PPIA
SH2D2A
SMAD4
SMURF1
SOCS1
SPRR2A
SRC
TGFBR1
WAS
54 interacting genes:
AXL
BLK
COMMD1
CRK
CSF1
CSF1R
CUEDC2
CXCR4
CYTIP
EGFR
ELOB
ELOC
ERBB2
ERBB4
FLT3
FYN
GHR
GRB2
IFNAR1
IFNGR1
IGF1R
IL2RB
INSR
IRF7
IRS1
IRS2
ITK
JAK1
JAK2
JAK3
KIT
LCK
LYN
MET
MIR924HG
MPL
NCK1
PDGFRB
PIK3R1
PIK3R2
PIM2
PTK2
RELA
SH3GL1
SRC
TEC
TEK
TIRAP
TP53
TRIM8
TYK2
VAV1
VAV2
YES1
Entrez ID
3702
8651
HPRD ID
01746
04669
Ensembl ID
ENSG00000113263
ENSG00000185338
Uniprot IDs
Q08881
O15524
Q4JHT5
PDB IDs
1SM2
1SNU
1SNX
2E6I
2LMJ
2YUQ
3MIY
3MJ1
3MJ2
3QGW
3QGY
3T9T
3V5J
3V5L
3V8T
3V8W
4HCT
4HCU
4HCV
4KIO
4L7S
4M0Y
4M0Z
4M12
4M13
4M14
4M15
4MF0
4MF1
4PP9
4PPA
4PPB
4PPC
4PQN
4QD6
4RFM
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
T Cell Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Cell Activation
Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Positive Regulation Of Signal Transduction
Phospholipase Binding
ERBB Signaling Pathway
Regulation Of Apoptotic Process
Immune System Process
Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Protein Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Immune Response
Intracellular Signaling Cassette
Leukocyte Activation
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Kinase Activity
Regulation Of Immune Response
Regulation Of MAPK Cascade
Membrane Raft
Positive Regulation Of Immune System Process
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Phosphorylation
Negative Regulation Of Programmed Cell Death
ERBB2 Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Kinase Activity
Peptidyl-tyrosine Phosphorylation
Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune System Process
Protein Phosphorylation
Cytokine-mediated Signaling Pathway
Regulation Of Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Activity
Phosphorylation
Regulation Of Signal Transduction
Receptor Complex
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Immune System Process
Protein Phosphatase Binding
Regulation Of Immune System Process
Phosphatidylinositol 3-kinase Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Positive Regulation Of MAPK Cascade
Protein Autophosphorylation
Leukocyte Activation
Cell Activation
Regulation Of MAPK Cascade
Growth Hormone Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
ATP Binding
Immune Response-activating Signaling Pathway
Positive Regulation Of Metabolic Process
Phosphotyrosine Residue Binding
Regulation Of Immune Response
Plasma Membrane
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
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Tagcloud (Intersection)
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