ITK and FGFR1

Number of citations of the paper that reports this interaction (PMID 22974441)
2

Data Source:
BioGRID (unspecified method)

		ITK	FGFR1
Gene Name		IL2-inducible T-cell kinase	fibroblast growth factor receptor 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Extracellular Region Nucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Receptor Complex
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Interferon-gamma Production Interleukin-4 Production Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway T Cell Activation Regulation Of Cell Proliferation Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Angiogenesis Ureteric Bud Development In Utero Embryonic Development Organ Induction Neuron Migration Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Transcription, DNA-templated Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Ventricular Zone Neuroblast Division Embryonic Limb Morphogenesis Midbrain Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Inner Ear Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Paraxial Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Cell Maturation Skeletal System Morphogenesis Mesenchymal Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Auditory Receptor Cell Development Branching Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		TCR signaling Generation of second messenger molecules Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System	Signaling by FGFR in disease Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants Signaling by FGFR mutants
Drugs		Staurosporine Pazopanib
Diseases
GWAS		Personality dimensions ( 21368711)
Protein-Protein Interactions		29 interactors: BLNK BMX BTK CBL CD28 DOK1 ERBB2 ERBB3 FASLG FGFR1 FYN GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 PLCG1 PLCG2 PPIA SH2D2A SMAD4 SOCS1 SPRR2A SRC TGFBR1 WAS	45 interactors: BNIP2 CREBBP CRK CTPS2 EPHA4 ERBB3 FDPS FGF1 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 IL17RD ITK KPNB1 MMP2 NCAM1 NCK1 NCK2 NEDD4 NRP1 PIK3R1 PIK3R2 PLCG1 PTK6 RPS6KA1 RPS6KA3 RTN3 SH3BP2 SHC1 SLA SOS1 TNS2 VAV1
Entrez ID		3702	2260
HPRD ID		01746	00634
Ensembl ID		ENSG00000113263	ENSG00000077782
Uniprot IDs		Q08881	P11362
PDB IDs		1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO	1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Immune Response Positive Regulation Of Signal Transduction Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Signal Transduction Antigen Receptor-mediated Signaling Pathway Defense Response Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Signaling ERBB Signaling Pathway Cell Communication T Cell Receptor Signaling Pathway Intracellular Signal Transduction Cell Activation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Wound Healing Regulation Of Immune System Process Cellular Response To Stimulus Response To Wounding Cellular Response To Growth Factor Stimulus Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Stress Neurotrophin Signaling Pathway Positive Regulation Of Immune Response Regulation Of Signal Transduction Response To Organic Substance Blood Coagulation Hemostasis Positive Regulation Of Intracellular Signal Transduction Platelet Activation Regulation Of Signaling Positive Regulation Of Immune System Process Phosphatidylinositol-mediated Signaling Cell Differentiation Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Organic Substance	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Fc Receptor Signaling Pathway Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Immune Response Cellular Response To Insulin Stimulus Cellular Response To Organic Substance Defense Response Cell Surface Receptor Signaling Pathway Response To Insulin Regulation Of Immune System Process Cellular Response To Peptide Hormone Stimulus Immune System Process Cellular Response To Peptide Signal Transduction Cellular Response To Organonitrogen Compound Response To Organic Substance Signaling Cell Communication Response To Peptide Hormone Response To Peptide Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cellular Response To Stimulus Response To Stress Locomotion Positive Regulation Of Signal Transduction Response To Organonitrogen Compound System Development Chemotaxis Multicellular Organismal Development Cell Differentiation Response To Hormone Regulation Of Phosphorylation Anatomical Structure Development
Tagcloud ?		adrenergic ark bind btk coincides computer databases defects difficult difficulty domains find homologues homology hypothesis irs overcome ph pleckstrin program programs simple substrate teca termini transduction trimeric unrecognized widely	abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings
Tagcloud (Difference) ?		adrenergic ark bind btk coincides computer databases defects difficult difficulty domains find homologues homology hypothesis irs overcome ph pleckstrin program programs simple substrate teca termini transduction trimeric unrecognized widely	abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings
Tagcloud (Intersection) ?