ITK and SPRR2A

Number of citations of the paper that reports this interaction (PMID 18155796)
10

Data Source:
BioGRID (pull down)

		ITK	SPRR2A
Gene Name		IL2-inducible T-cell kinase	small proline-rich protein 2A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cornified Envelope Cytoplasm
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Interferon-gamma Production Interleukin-4 Production Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway T Cell Activation Regulation Of Cell Proliferation Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Epidermis Development Keratinocyte Differentiation Keratinization
Pathways		TCR signaling Generation of second messenger molecules Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System
Drugs		Staurosporine Pazopanib
Diseases
GWAS		Personality dimensions ( 21368711)
Protein-Protein Interactions		29 interactors: BLNK BMX BTK CBL CD28 DOK1 ERBB2 ERBB3 FASLG FGFR1 FYN GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 PLCG1 PLCG2 PPIA SH2D2A SMAD4 SOCS1 SPRR2A SRC TGFBR1 WAS	10 interactors: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 YES1
Entrez ID		3702	6700
HPRD ID		01746	01649
Ensembl ID		ENSG00000113263	ENSG00000241794
Uniprot IDs		Q08881	P35326
PDB IDs		1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Immune Response Positive Regulation Of Signal Transduction Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Signal Transduction Antigen Receptor-mediated Signaling Pathway Defense Response Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Signaling ERBB Signaling Pathway Cell Communication T Cell Receptor Signaling Pathway Intracellular Signal Transduction Cell Activation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Wound Healing Regulation Of Immune System Process Cellular Response To Stimulus Response To Wounding Cellular Response To Growth Factor Stimulus Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Stress Neurotrophin Signaling Pathway Positive Regulation Of Immune Response Regulation Of Signal Transduction Response To Organic Substance Blood Coagulation Hemostasis Positive Regulation Of Intracellular Signal Transduction Platelet Activation Regulation Of Signaling Positive Regulation Of Immune System Process Phosphatidylinositol-mediated Signaling Cell Differentiation Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Organic Substance	Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Protein Autophosphorylation Phagocytosis Positive Regulation Of Immune Response Locomotion Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Hormone Stimulus Anatomical Structure Development Cellular Response To Peptide Vesicle-mediated Transport Innate Immune Response Movement Of Cell Or Subcellular Component Regulation Of Actin Cytoskeleton Organization Response To Organonitrogen Compound Regulation Of Vesicle-mediated Transport Cell Migration Regulation Of Immune Response Developmental Process Regulation Of Actin Filament-based Process Positive Regulation Of Immune System Process Cell Motility Regulation Of Organelle Organization Neurogenesis Response To Peptide Hormone Dendritic Spine Organization System Development Response To Peptide Phosphorylation Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Endocytosis Cellular Response To Hormone Stimulus Multicellular Organismal Development Immune Response Neuron Projection Morphogenesis Regulation Of Immune System Process Protein Phosphorylation Transport
Tagcloud ?		adrenergic ark bind btk coincides computer databases defects difficult difficulty domains find homologues homology hypothesis irs overcome ph pleckstrin program programs simple substrate teca termini transduction trimeric unrecognized widely	200c bec biliary cc cholangiocarcinogenesis cholangiocarcinomas ck19 ctbp dephosphorylation emt healing intrahepatic invasiveness labeling microrna modulates morphometric multiplex nonneoplastic proline protects proteomic quenches radicals sh3 synergic wound zeb zeb1
Tagcloud (Difference) ?		adrenergic ark bind btk coincides computer databases defects difficult difficulty domains find homologues homology hypothesis irs overcome ph pleckstrin program programs simple substrate teca termini transduction trimeric unrecognized widely	200c bec biliary cc cholangiocarcinogenesis cholangiocarcinomas ck19 ctbp dephosphorylation emt healing intrahepatic invasiveness labeling microrna modulates morphometric multiplex nonneoplastic proline protects proteomic quenches radicals sh3 synergic wound zeb zeb1
Tagcloud (Intersection) ?