TNFRSF11B and THBS1

Number of citations of the paper that reports this interaction (PMID 15799029)
17

Data Source:
HPRD (in vivo)

		TNFRSF11B	THBS1
Gene Name		tumor necrosis factor receptor superfamily, member 11b	thrombospondin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Cytokine Activity	Phosphatidylserine Binding Glycoprotein Binding Fibronectin Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Fibrinogen Binding Collagen V Binding
	Biological Process	Skeletal System Development Apoptotic Process Signal Transduction Response To Nutrient Extracellular Matrix Organization Response To Magnesium Ion Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Estrogen Negative Regulation Of Bone Resorption Response To Arsenic-containing Substance	Activation Of MAPK Activity Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Platelet Degranulation Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Outflow Tract Morphogenesis Endocardial Cushion Development Growth Plate Cartilage Development Protein O-linked Glycosylation Immune Response Response To Unfolded Protein Cell Cycle Arrest Cell Adhesion Blood Coagulation Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Peptide Cross-linking Platelet Activation Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of CGMP Metabolic Process Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-12 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Protein O-linked Fucosylation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Signaling by PDGF Post-translational protein modification Non-integrin membrane-ECM interactions Platelet degranulation O-glycosylation of TSR domain-containing proteins O-linked glycosylation Syndecan interactions Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Bone mineral density ( 18455228 23437003 22504420) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Osteoporosis ( 20548944) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		7 interactors: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF	39 interactors: CALCR CALR CD36 CD47 CFH COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL7A1 CORO1A CTSG DCN DHFR ELANE F2 FGA FGF2 FN1 HRG IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 PDGFB PLG SCARB2 SPARC TFPI TGFB1 TNFAIP6 TNFRSF11B
Entrez ID		4982	7057
HPRD ID		04032	01765
Ensembl ID		ENSG00000164761
Uniprot IDs		O00300	P07996
PDB IDs		3URF	1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Immune System Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Positive Regulation Of Cellular Metabolic Process Platelet Activation Regulation Of Proteolysis Cell-substrate Adhesion Regulation Of Fatty Acid Transport Endodermal Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Activation Regulation Of Cellular Protein Metabolic Process Peptide Cross-linking Positive Regulation Of Wound Healing Exocytosis Endoderm Formation Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Regulation Of Endopeptidase Activity Regulation Of Catalytic Activity Blood Coagulation Hemostasis Regulation Of Acute Inflammatory Response Cell Adhesion Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Activation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Endoderm Development Regulation Of Immune System Process Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Corticotropin-releasing Hormone Secretion Secretion By Cell Regulation Of Lipid Transport Regulation Of Blood Coagulation Multicellular Organismal Development Cellular Response To Tumor Necrosis Factor Vesicle-mediated Transport Anatomical Structure Development Regulation Of Body Fluid Levels Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Catalytic Activity Wound Healing Regulation Of Cell Adhesion	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Wound Healing Platelet Activation Response To Wounding Platelet Degranulation Blood Coagulation Hemostasis Vesicle-mediated Transport Collagen Catabolic Process Regulation Of Locomotion Response To External Stimulus Collagen Metabolic Process Regulation Of Body Fluid Levels Cardiovascular System Development Regulation Of Cell Migration Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Regulation Of Cell Motility Blood Vessel Development Vasculature Development Response To Stimulus Regulation Of Cellular Component Movement Tissue Development Response To Stress Leukocyte Migration Response To Organic Substance Movement Of Cell Or Subcellular Component Negative Regulation Of Wound Healing Endocytosis Cell Migration Regulation Of Wound Healing Cell Activation Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Anatomical Structure Morphogenesis Exocytosis Positive Regulation Of Cellular Component Movement Immune System Process Positive Regulation Of Locomotion Regulation Of Blood Coagulation Multicellular Organismal Development Negative Regulation Of Blood Coagulation Anatomical Structure Development Negative Regulation Of Coagulation System Development
Tagcloud ?		arterial atherosclerosis atherosclerotic belongs causative cli concomitantly controversial cvd depending epidemiological females g1181c genotypes glycoprotein infarction males mediating occlusive opg osteoprotegerin paod polymorphisms restriction secretory synergistic synergistically t245g t950c	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2
Tagcloud (Difference) ?		arterial atherosclerosis atherosclerotic belongs causative cli concomitantly controversial cvd depending epidemiological females g1181c genotypes glycoprotein infarction males mediating occlusive opg osteoprotegerin paod polymorphisms restriction secretory synergistic synergistically t245g t950c	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2
Tagcloud (Intersection) ?