TNFRSF11B and VWF

Number of citations of the paper that reports this interaction (PubMedID 15799029)
0

Data Source:
HPRD (in vivo)

		TNFRSF11B	VWF
Description		TNF receptor superfamily member 11b	von Willebrand factor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Exosome Cell Periphery
	Molecular Function	Cytokine Activity Protein Binding Signaling Receptor Activity Heparan Sulfate Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein-folding Chaperone Binding
	Biological Process	Skeletal System Development Apoptotic Process Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Osteoclast Differentiation	Cell Adhesion Blood Coagulation Hemostasis Response To Wounding Platelet Activation Cell-substrate Adhesion Positive Regulation Of Intracellular Signal Transduction
Pathways		TNFs bind their physiological receptors	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V
Drugs			Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic factor (recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol Rurioctocog alfa pegol
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)	Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Asthma ( 29273806) Asthma (childhood onset) ( 30929738) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Bone mineral density ( 18455228 23437003 24249740) Bone mineral density (hip) ( 19801982 27311723) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Osteoporosis-related phenotypes ( 20548944) Osteoprotegerin levels ( 25080503) Physiological traits ( 31902109) Serum alkaline phosphatase levels ( 29403010 31666285 33547301) Serum sclerostin levels ( 31170332) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 21980299)	Coagulation factor levels ( 23267103) Factor VIII levels ( 20231535 30586737) Low vWF levels ( 26486471) Mean platelet volume ( 22139419 27863252 32888494) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 22139419 26805783 32888494) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		7 interacting genes: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF	28 interacting genes: ADAMTS13 ALB APOA1 ATXN7 CACNA1A CALR COL1A1 COL1A2 COL3A1 F8 FGA FGB FGG FURIN FXR1 GP1BA HOXA1 HSPA5 ITGA2B LCOR MAP3K3 NUFIP2 P4HB PROS1 RAC1 SOCS4 TNFRSF11B ZNF512B
Entrez ID		4982	7450
HPRD ID		04032	01906
Ensembl ID		ENSG00000164761	ENSG00000110799
Uniprot IDs		O00300	P04275
PDB IDs		3URF	1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 2MHP 2MHQ 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4C29 4C2A 4C2B 4DMU 4NT5 5BV8 6FWN 6N29 7EOW 7F49 7KWO 7P4N 7PMV 7PNF 7ZWH 8D3C 8D3D
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Matrix Structural Constituent Integrin Binding Tumor Necrosis Factor Receptor Binding Extracellular Region Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Collagen Binding Platelet Alpha Granule Lumen Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Signal Transduction Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Cell Communication Signaling Receptor Binding Protease Binding Positive Regulation Of Signaling Negative Regulation Of Fibrinolysis Extracellular Matrix Proteoglycan Binding Extracellular Exosome Regulation Of Fibrinolysis Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Activation Cascade Heparin Binding Cell-substrate Adhesion Platelet Alpha Granule Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response Positive Regulation Of Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Activation Positive Regulation Of Coagulation Extracellular Matrix Binding Cytokine Activity Regulation Of Fatty Acid Transport Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Cell Adhesion Identical Protein Binding Cell Migration Immune System Process Positive Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Cell Communication	Endoplasmic Reticulum Lumen Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Fibrinolysis Protein Activation Cascade Cell-matrix Adhesion Coagulation Blood Coagulation Hemostasis Platelet Alpha Granule Lumen Blood Microparticle Platelet Activation Positive Regulation Of Cell-substrate Adhesion Protein Maturation Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Space Negative Regulation Of Coagulation Extracellular Matrix Structural Constituent Positive Regulation Of Rho Protein Signal Transduction Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinogen Complex Extracellular Region Extracellular Matrix Fibrillar Collagen Trimer Regulation Of Body Fluid Levels Blood Coagulation, Fibrin Clot Formation Zymogen Activation Protein Processing Regulation Of Biological Quality Platelet-derived Growth Factor Binding Plasminogen Activation Cell Surface Regulation Of Signal Transduction Regulation Of Signaling Protein Folding In Endoplasmic Reticulum Regulation Of Cell Communication Positive Regulation Of Heterotypic Cell-cell Adhesion External Side Of Plasma Membrane Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Collagen Type I Trimer Extracellular Matrix Organization Regulation Of Wound Healing Extracellular Structure Organization Platelet Alpha Granule
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