TNFRSF11B and TNFSF11

Number of citations of the paper that reports this interaction (PMID 9520411)
406

Data Source:
HPRD (in vivo)

		TNFRSF11B	TNFSF11
Gene Name		tumor necrosis factor receptor superfamily, member 11b	tumor necrosis factor (ligand) superfamily, member 11
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space	Extracellular Region Extracellular Space Cytoplasm Integral Component Of Plasma Membrane
	Molecular Function	Receptor Activity Cytokine Activity	Cytokine Activity Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor Receptor Superfamily Binding
	Biological Process	Skeletal System Development Apoptotic Process Signal Transduction Response To Nutrient Extracellular Matrix Organization Response To Magnesium Ion Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Estrogen Negative Regulation Of Bone Resorption Response To Arsenic-containing Substance	Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Activation Of JUN Kinase Activity Organ Morphogenesis Cytokine-mediated Signaling Pathway Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Bone Resorption Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Protein Kinase B Signaling Calcium Ion Homeostasis Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Osteoclast Development
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 18455228 23437003 22504420) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Osteoporosis ( 20548944) Type 1 diabetes ( 21980299)	Bone mineral density ( 23437003) Cortical thickness ( 22792071) Crohn's disease ( 21102463)
Protein-Protein Interactions		7 interactors: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF	31 interactors: ADAM17 ADAM19 AKT1 BBS10 DDAH2 EEF1A1 EZH2 FAM213B KHDRBS1 KIAA1377 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA PHAX PLK1 SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A ZC3HC1
Entrez ID		4982	8600
HPRD ID		04032	04031
Ensembl ID		ENSG00000164761	ENSG00000120659
Uniprot IDs		O00300	O14788 Q54A98 Q5T9Y4
PDB IDs		3URF	3URF
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Immune System Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Positive Regulation Of Cellular Metabolic Process Platelet Activation Regulation Of Proteolysis Cell-substrate Adhesion Regulation Of Fatty Acid Transport Endodermal Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Activation Regulation Of Cellular Protein Metabolic Process Peptide Cross-linking Positive Regulation Of Wound Healing Exocytosis Endoderm Formation Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Regulation Of Endopeptidase Activity Regulation Of Catalytic Activity Blood Coagulation Hemostasis Regulation Of Acute Inflammatory Response Cell Adhesion Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Activation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Endoderm Development Regulation Of Immune System Process Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Corticotropin-releasing Hormone Secretion Secretion By Cell Regulation Of Lipid Transport Regulation Of Blood Coagulation Multicellular Organismal Development Cellular Response To Tumor Necrosis Factor Vesicle-mediated Transport Anatomical Structure Development Regulation Of Body Fluid Levels Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Catalytic Activity Wound Healing Regulation Of Cell Adhesion	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Membrane Protein Proteolysis Toll-like Receptor 4 Signaling Pathway Response To Lipopolysaccharide Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Bacterium Membrane Protein Intracellular Domain Proteolysis Response To Molecule Of Bacterial Origin Fc-epsilon Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Transferase Activity Activation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Cellular Response To Lipopolysaccharide Response To Growth Factor Response To Epidermal Growth Factor Fc Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Other Organism Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Biotic Stimulus Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Cell Death Death Regulation Of Innate Immune Response
Tagcloud ?		arterial atherosclerosis atherosclerotic belongs causative cli concomitantly controversial cvd depending epidemiological females g1181c genotypes glycoprotein infarction males mediating occlusive opg osteoprotegerin paod polymorphisms restriction secretory synergistic synergistically t245g t950c	actors apatite autophagic autophagy calcified corals crystals extend favoring mechanosensing mineralization mineralized mineralizing multifunctional nfkb1 ob oc osteoblasts osteocytes osteoporosis pathologies resorption secrete specialized trabecular uncover vacuoles vehicles vertebrates
Tagcloud (Difference) ?		arterial atherosclerosis atherosclerotic belongs causative cli concomitantly controversial cvd depending epidemiological females g1181c genotypes glycoprotein infarction males mediating occlusive opg osteoprotegerin paod polymorphisms restriction secretory synergistic synergistically t245g t950c	actors apatite autophagic autophagy calcified corals crystals extend favoring mechanosensing mineralization mineralized mineralizing multifunctional nfkb1 ob oc osteoblasts osteocytes osteoporosis pathologies resorption secrete specialized trabecular uncover vacuoles vehicles vertebrates
Tagcloud (Intersection) ?