TNFRSF11B and TNFSF13

Number of citations of the paper that reports this interaction (PubMedID 10706119)
0

Data Source:
HPRD (in vitro)

		TNFRSF11B	TNFSF13
Description		TNF receptor superfamily member 11b	TNF superfamily member 13
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Receptor Complex	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Signaling Receptor Activity Heparan Sulfate Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Skeletal System Development Apoptotic Process Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Osteoclast Differentiation	Lymphocyte Homeostasis Immune System Process Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Isotype Switching To IgA Isotypes
Pathways		TNFs bind their physiological receptors	HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors
Drugs
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Asthma ( 29273806) Asthma (childhood onset) ( 30929738) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Bone mineral density ( 18455228 23437003 24249740) Bone mineral density (hip) ( 19801982 27311723) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Osteoporosis-related phenotypes ( 20548944) Osteoprotegerin levels ( 25080503) Physiological traits ( 31902109) Serum alkaline phosphatase levels ( 29403010 31666285 33547301) Serum sclerostin levels ( 31170332) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 21980299)	Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 28628107 22864923) IgA nephropathy ( 22197929 26028593 25305756) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 29403010 22558069) Serum total protein levels ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		7 interacting genes: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF	13 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 SGTB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B
Entrez ID		4982	8741
HPRD ID		04032	05128
Ensembl ID		ENSG00000164761	ENSG00000161955
Uniprot IDs		O00300	O75888 Q2QBA2
PDB IDs		3URF	4ZCH
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Matrix Structural Constituent Integrin Binding Tumor Necrosis Factor Receptor Binding Extracellular Region Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Collagen Binding Platelet Alpha Granule Lumen Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Signal Transduction Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Cell Communication Signaling Receptor Binding Protease Binding Positive Regulation Of Signaling Negative Regulation Of Fibrinolysis Extracellular Matrix Proteoglycan Binding Extracellular Exosome Regulation Of Fibrinolysis Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Activation Cascade Heparin Binding Cell-substrate Adhesion Platelet Alpha Granule Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response Positive Regulation Of Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Activation Positive Regulation Of Coagulation Extracellular Matrix Binding Cytokine Activity Regulation Of Fatty Acid Transport Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Cell Adhesion Identical Protein Binding Cell Migration Immune System Process Positive Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Cell Communication	Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity Cytokine-mediated Signaling Pathway Signaling Receptor Activity Cell Surface Receptor Signaling Pathway Signal Transduction Homeostasis Of Number Of Cells Lymphocyte Homeostasis Heparan Sulfate Binding Plasma Membrane Multicellular Organismal-level Homeostasis Leukocyte Homeostasis Adaptive Immune Response Regulation Of Immune System Process B Cell Homeostasis Response To Mechanical Stimulus Cell Death Membrane Raft Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process Programmed Cell Death Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process T Cell Costimulation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Mononuclear Cell Proliferation Regulation Of Developmental Process Immune Response Cellular Response To Mechanical Stimulus Immune System Process Cell Surface Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Negative Regulation Of Adaptive Immune Memory Response Regulation Of Leukocyte Proliferation Positive Regulation Of Germinal Center Formation Regulation Of B Cell Proliferation Transitional One Stage B Cell Differentiation TRC Complex Homeostatic Process Fas Signaling Pathway GMP Binding
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