TNFRSF11B

Description		TNF receptor superfamily member 11b
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Signaling Receptor Activity Heparan Sulfate Binding
	Biological Process	Skeletal System Development Apoptotic Process Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Osteoclast Differentiation
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Asthma ( 29273806) Asthma (childhood onset) ( 30929738) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Bone mineral density ( 18455228 23437003 24249740) Bone mineral density (hip) ( 19801982 27311723) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Osteoporosis-related phenotypes ( 20548944) Osteoprotegerin levels ( 25080503) Physiological traits ( 31902109) Serum alkaline phosphatase levels ( 29403010 31666285 33547301) Serum sclerostin levels ( 31170332) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 21980299)
Interacting Genes		7 interacting genes: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF
Entrez ID		4982
HPRD ID		04032
Ensembl ID		ENSG00000164761
Uniprot IDs		O00300
PDB IDs		3URF
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Matrix Structural Constituent Integrin Binding Tumor Necrosis Factor Receptor Binding Extracellular Region Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Collagen Binding Platelet Alpha Granule Lumen Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Signal Transduction Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Cell Communication Signaling Receptor Binding Protease Binding Positive Regulation Of Signaling Negative Regulation Of Fibrinolysis Extracellular Matrix Proteoglycan Binding Extracellular Exosome Regulation Of Fibrinolysis Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Activation Cascade Heparin Binding Cell-substrate Adhesion Platelet Alpha Granule Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response Positive Regulation Of Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Activation Positive Regulation Of Coagulation Extracellular Matrix Binding Cytokine Activity Regulation Of Fatty Acid Transport Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Cell Adhesion Identical Protein Binding Cell Migration Immune System Process Positive Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Cell Communication
Tagcloud ?