ADH5 and ESRRA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ADH5	ESRRA
Description		alcohol dehydrogenase 5 (class III), chi polypeptide	estrogen related receptor alpha
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity Fatty Acid Binding Zinc Ion Binding Electron Transfer Activity Oxidoreductase Activity Formaldehyde Dehydrogenase (NAD+) Activity Identical Protein Binding Metal Ion Binding S-(hydroxymethyl)glutathione Dehydrogenase [NAD(P)+] Activity S-nitrosoglutathione Reductase (NADH) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NADP+) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NAD+) Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Retinoid Metabolic Process Respiratory System Process Lipid Metabolic Process Fatty Acid Omega-oxidation Response To Lipopolysaccharide Small Molecule Metabolic Process Positive Regulation Of Blood Pressure Formaldehyde Catabolic Process Response To Nitrosative Stress Response To Redox State	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Ethanol oxidation	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity
Drugs		NADH Lauric acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione	Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone
Diseases
GWAS		Alcohol consumption ( 28937693) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 23456092) Blood protein levels ( 30072576) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Regular attendance at a pub or social club ( 29970889)	Crohn's disease ( 21102463 28067908) Vitiligo ( 27723757)
Interacting Genes		10 interacting genes: APP ARNT CHD3 CSNK2B ESRRA PRDX1 SLC66A2 SNTA1 USP40 VTN	37 interacting genes: ADH5 ATXN1 DUT ESR1 ESRRG EXOSC6 FAM9A FUS GTF2B HDAC8 HIF1A KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA2 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARG PPARGC1A PRKCD PROX1 PSMC5 REL RNF4 RXRA SIRT1 SMARCD3 SP1 TNNI2
Entrez ID		128	2101
HPRD ID		00064	07210
Ensembl ID		ENSG00000197894	ENSG00000173153
Uniprot IDs		P11766 Q6IRT1	P11474 Q569H8
PDB IDs		1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5 8GV3	1XB7 2PJL 3D24 3K6P 7E2E
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Positive Regulation Of Glycolytic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of ATP Metabolic Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Nuclear Receptor Activity Symbiont-containing Vacuole Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Golgi Lumen Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Catabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Nuclear Aryl Hydrocarbon Receptor Complex Response To Oxidative Stress Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Smooth Muscle Cell-matrix Adhesion Rough Endoplasmic Reticulum Lumen Alphav-beta3 Integrin-vitronectin Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Norepinephrine Stimulus Negative Regulation Of Macromolecule Metabolic Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling PML Body Syntrophin Complex	Nuclear Receptor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Positive Regulation Of Metabolic Process Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Nuclear Retinoid X Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Adipose Tissue Development Negative Regulation Of Metabolic Process Regulation Of Lipid Metabolic Process Transcription Coregulator Binding Nuclear Retinoic Acid Receptor Binding DNA Binding Domain Binding Regulation Of Adipose Tissue Development Retinoic Acid Receptor Signaling Pathway Transcription By RNA Polymerase II Protein-lysine-acetyltransferase Activity LBD Domain Binding Circadian Regulation Of Gene Expression
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