ADH5 and CHD3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ADH5	CHD3
Gene Name		alcohol dehydrogenase 5 (class III), chi polypeptide	chromodomain helicase DNA binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome NuRD Complex Intermediate Filament Cytoskeleton
	Molecular Function	Alcohol Dehydrogenase (NAD) Activity Fatty Acid Binding Zinc Ion Binding Electron Carrier Activity Formaldehyde Dehydrogenase Activity Protein Homodimerization Activity S-(hydroxymethyl)glutathione Dehydrogenase Activity	DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Retinoid Metabolic Process Respiratory System Process Ethanol Catabolic Process Ethanol Oxidation Aging Peptidyl-cysteine S-nitrosylation Response To Lipopolysaccharide Positive Regulation Of Blood Pressure Formaldehyde Catabolic Process Response To Nitrosative Stress Response To Redox State	Chromatin Organization Chromatin Assembly Or Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spindle Organization Chromatin Modification DNA Duplex Unwinding Centrosome Organization
Pathways			Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
Diseases
GWAS		Alcohol dependence ( 23456092) Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: APP ARNT CHD3 CSNK2B ESRRA PQLC1 PRDX1 SNTA1 VTN	90 interactors: ACTR1B ADH5 AIMP2 ATPIF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CPE CRCT1 CREB1 CSTF2 CTBP1 CTTN FABP4 FAM134A FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RGS2 RIF1 RPL29 SAFB SAT1 SATB1 SDCCAG3 SERBP1 SERF2 SGSM2 SIRT6 SKIL SLC27A6 SRRT SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBE2I UROD VIM XRCC4 YAE1D1 ZHX1
Entrez ID		128	1107
HPRD ID		00064	09071
Ensembl ID		ENSG00000197894	ENSG00000170004
Uniprot IDs		P11766 Q6IRT1	B3KWV4 Q12873 Q2TAZ1
PDB IDs		1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Binding Regulation Of Metabolic Process Neuromuscular Junction Development Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Vasoconstriction By Circulating Norepinephrine Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Hormone-mediated Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Binding Multicellular Organismal Development Regulation Of Cellular Component Movement Synapse Organization Anatomical Structure Development Regulation Of Myeloid Cell Differentiation Regulation Of Signaling Regulation Of Nitrogen Compound Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Cellular Response To Growth Factor Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Cellular Response To Oxidative Stress Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Axon Choice Point Recognition Positive Regulation Of Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Developmental Process Adiponectin-activated Signaling Pathway Neuron Remodeling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity	Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process RNA Metabolic Process RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Biosynthetic Process Protein Sumoylation Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Cellular Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Positive Regulation Of Organelle Organization Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Programmed Cell Death B Cell Activation Cellular Process Negative Regulation Of Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Death Programmed Cell Death Cell Differentiation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Negative Regulation Of Apoptotic Process Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process
Tagcloud ?			ancestor animal arabidopsis atp codes deacetylation exhibits exists mi monomer mononucleosomes multisubunit naked nurd pickle planta promotes remodeler remodelers remodeling restrict retain share ssdna subfamily thaliana trimethylation ubiquitous
Tagcloud (Difference) ?			ancestor animal arabidopsis atp codes deacetylation exhibits exists mi monomer mononucleosomes multisubunit naked nurd pickle planta promotes remodeler remodelers remodeling restrict retain share ssdna subfamily thaliana trimethylation ubiquitous
Tagcloud (Intersection) ?