ADH5 and ARNT

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADH5	ARNT
Gene Name		alcohol dehydrogenase 5 (class III), chi polypeptide	aryl hydrocarbon receptor nuclear translocator
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Alcohol Dehydrogenase (NAD) Activity Fatty Acid Binding Zinc Ion Binding Electron Carrier Activity Formaldehyde Dehydrogenase Activity Protein Homodimerization Activity S-(hydroxymethyl)glutathione Dehydrogenase Activity	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Aryl Hydrocarbon Receptor Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding Enhancer Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Retinoid Metabolic Process Respiratory System Process Ethanol Catabolic Process Ethanol Oxidation Aging Peptidyl-cysteine S-nitrosylation Response To Lipopolysaccharide Positive Regulation Of Blood Pressure Formaldehyde Catabolic Process Response To Nitrosative Stress Response To Redox State	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Transcription, DNA-templated Positive Regulation Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways			Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Regulation of gene expression by Hypoxia-inducible Factor
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
Diseases
GWAS		Alcohol dependence ( 23456092) Obesity-related traits ( 23251661)	Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552) Urate levels ( 23263486)
Protein-Protein Interactions		9 interactors: APP ARNT CHD3 CSNK2B ESRRA PQLC1 PRDX1 SNTA1 VTN	37 interactors: ADH5 AHR AHRR AIP ARNT2 BRCA1 CSNK2A1 DIABLO EP300 EPAS1 ESR1 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HIF1A IRAK4 LSM8 MTA3 NCOA1 NCOA2 NCOA7 NCOR2 NPAS4 PML PTGES3 SENP6 SIM1 SIM2 SMAD9 SP1 SRC STRBP TNFAIP1 TRIP11 UBE2I
Entrez ID		128	405
HPRD ID		00064	00524
Ensembl ID		ENSG00000197894	ENSG00000143437
Uniprot IDs		P11766 Q6IRT1	A8K6P0 B0AZM1 F8WAP6 P27540
PDB IDs		1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5	1D7G 1X0O 2A24 2ARN 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Binding Regulation Of Metabolic Process Neuromuscular Junction Development Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Vasoconstriction By Circulating Norepinephrine Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Hormone-mediated Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Binding Multicellular Organismal Development Regulation Of Cellular Component Movement Synapse Organization Anatomical Structure Development Regulation Of Myeloid Cell Differentiation Regulation Of Signaling Regulation Of Nitrogen Compound Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Cellular Response To Growth Factor Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Cellular Response To Oxidative Stress Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Axon Choice Point Recognition Positive Regulation Of Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Developmental Process Adiponectin-activated Signaling Pathway Neuron Remodeling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Rhythmic Process Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Tube Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Signaling Intracellular Receptor Signaling Pathway Embryonic Placenta Development Cell Communication Reproductive Structure Development Response To Stimulus Negative Regulation Of Biosynthetic Process Reproductive System Development Regulation Of Cellular Process Embryo Development Organ Development Single Organism Reproductive Process Multicellular Organismal Development
Tagcloud ?			belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections
Tagcloud (Difference) ?			belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections
Tagcloud (Intersection) ?