ADH5 and VTN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ADH5	VTN
Description		alcohol dehydrogenase 5 (class III), chi polypeptide	vitronectin
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Golgi Lumen Symbiont-containing Vacuole Extracellular Matrix Rough Endoplasmic Reticulum Lumen Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle Protein Complex Involved In Cell-matrix Adhesion Peptidase Inhibitor Complex
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity Fatty Acid Binding Zinc Ion Binding Electron Transfer Activity Oxidoreductase Activity Formaldehyde Dehydrogenase (NAD+) Activity Identical Protein Binding Metal Ion Binding S-(hydroxymethyl)glutathione Dehydrogenase [NAD(P)+] Activity S-nitrosoglutathione Reductase (NADH) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NADP+) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NAD+) Activity	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Polysaccharide Binding Identical Protein Binding Extracellular Matrix Binding
	Biological Process	Retinoid Metabolic Process Respiratory System Process Lipid Metabolic Process Fatty Acid Omega-oxidation Response To Lipopolysaccharide Small Molecule Metabolic Process Positive Regulation Of Blood Pressure Formaldehyde Catabolic Process Response To Nitrosative Stress Response To Redox State	Immune Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Smooth Muscle Cell Migration Vesicle-mediated Transport Cell Migration Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Oligodendrocyte Differentiation Protein Polymerization Negative Regulation Of Fibrinolysis Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing Liver Regeneration Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Ethanol oxidation	Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade Developmental Lineage of Pancreatic Ductal Cells
Drugs		NADH Lauric acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione	Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alcohol consumption ( 28937693) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 23456092) Blood protein levels ( 30072576) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Regular attendance at a pub or social club ( 29970889)	Advanced age-related macular degeneration ( 26691988) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731 33339817) Osteoprotegerin levels ( 25080503)
Interacting Genes		10 interacting genes: APP ARNT CHD3 CSNK2B ESRRA PRDX1 SLC66A2 SNTA1 USP40 VTN	50 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA2B ITGA5 ITGA8 ITGAV ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA
Entrez ID		128	7448
HPRD ID		00064	01902
Ensembl ID		ENSG00000197894	ENSG00000109072
Uniprot IDs		P11766 Q6IRT1	D9ZGG2 P04004
PDB IDs		1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5 8GV3	1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E 7RJ9
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Positive Regulation Of Glycolytic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of ATP Metabolic Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Nuclear Receptor Activity Symbiont-containing Vacuole Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Golgi Lumen Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Catabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Nuclear Aryl Hydrocarbon Receptor Complex Response To Oxidative Stress Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Smooth Muscle Cell-matrix Adhesion Rough Endoplasmic Reticulum Lumen Alphav-beta3 Integrin-vitronectin Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Norepinephrine Stimulus Negative Regulation Of Macromolecule Metabolic Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling PML Body Syntrophin Complex	Platelet Alpha Granule Lumen Integrin Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Integrin Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-matrix Adhesion Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Locomotion Cell-cell Adhesion Positive Regulation Of Vasculature Development Cell Surface Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Signaling Receptor Binding Negative Regulation Of Multicellular Organismal Process Cell Adhesion Growth Factor Activity Angiogenesis Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Protein Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Alphav-beta3 Integrin-PKCalpha Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Transport Positive Regulation Of Angiogenesis Positive Regulation Of Protein Localization Regulation Of Morphogenesis Of An Epithelium Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Cell Migration Positive Regulation Of Morphogenesis Of An Epithelium
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