PAK2 and ARHGEF6

Number of citations of the paper that reports this interaction (PMID 16374509)
26

Data Source:
HPRD (in vitro)

		PAK2	ARHGEF6
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 2	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Intracellular Cytosol Cell-cell Junction Lamellipodium
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Axon Guidance Viral Process Phosphorylation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Apoptotic Process JNK Cascade Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rho GTPase Activity Cell Junction Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Regulation of PAK-2p34 activity by PS-GAP/RHG10 Costimulation by the CD28 family Axon guidance HIV Infection FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Nef and signal transduction Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability Programmed Cell Death EPH-Ephrin signaling Innate Immune System Generation of second messenger molecules Semaphorin interactions Apoptotic execution phase CD28 co-stimulation Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis CD28 dependent Vav1 pathway Stimulation of the cell death response by PAK-2p34 TCR signaling Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Regulation of Apoptosis Adaptive Immune System	Signaling by GPCR Cell junction organization Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G alpha (12/13) signalling events Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Total ventricular volume ( 21116278)
Protein-Protein Interactions		51 interactors: ABI1 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 HCK HIST1H4F LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 PACSIN3 RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1	22 interactors: ADAM15 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580
Entrez ID		5062	9459
HPRD ID		05428	02226
Ensembl ID		ENSG00000180370	ENSG00000129675
Uniprot IDs		A8K5M4 Q13177	B7Z3C7 Q15052 Q8N4Q3
PDB IDs		3PCS	1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Cytoskeleton Organization Chemotaxis Phagocytosis Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway Axon Development Cellular Response To Peptide Hormone Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Cellular Response To Peptide Cell Projection Organization Actin Filament-based Process Neuron Projection Morphogenesis Signal Transduction Signaling Response To Peptide Hormone Peptidyl-tyrosine Autophosphorylation Cell Communication Innate Immune Response Cellular Response To Organonitrogen Compound Cell Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Peptide Intracellular Signal Transduction Actin Cytoskeleton Organization Cell Projection Morphogenesis Regulation Of Immune System Process Cellular Response To Organic Substance Response To Growth Factor Cell Part Morphogenesis Programmed Cell Death	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Morphogenesis Cell Morphogenesis Involved In Differentiation Ephrin Receptor Signaling Pathway Cell Development Intracellular Signal Transduction Anatomical Structure Morphogenesis Axon Guidance Chemotaxis Signal Transduction By Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Differentiation Nervous System Development System Development Cell Morphogenesis Axonogenesis Primary MiRNA Processing Regulation Of Cellular Component Organization Axon Development Generation Of Neurons Positive Regulation Of Cell Differentiation Regulation Of Cell Development Regulation Of Signaling Regulation Of Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death SMAD Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neurogenesis Locomotion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Multicellular Organismal Development Signaling Regulation Of Signal Transduction Cell Communication Anatomical Structure Development Response To External Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Growth Positive Regulation Of Cell Development Regulation Of Cell Proliferation Heart Development Embryonic Cranial Skeleton Morphogenesis Signal Transduction
Tagcloud ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Difference) ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Intersection) ?