PAK2 and PACSIN3

Number of citations of the paper that reports this interaction (PMID 16374509)
26

Data Source:
HPRD (in vitro)

		PAK2	PACSIN3
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 2	protein kinase C and casein kinase substrate in neurons 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Endosome Plasma Membrane Membrane Membrane-bounded Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Axon Guidance Viral Process Phosphorylation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Membrane Tubulation
Pathways		Regulation of PAK-2p34 activity by PS-GAP/RHG10 Costimulation by the CD28 family Axon guidance HIV Infection FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Nef and signal transduction Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability Programmed Cell Death EPH-Ephrin signaling Innate Immune System Generation of second messenger molecules Semaphorin interactions Apoptotic execution phase CD28 co-stimulation Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis CD28 dependent Vav1 pathway Stimulation of the cell death response by PAK-2p34 TCR signaling Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Regulation of Apoptosis Adaptive Immune System
Drugs
Diseases
GWAS		Total ventricular volume ( 21116278)
Protein-Protein Interactions		51 interactors: ABI1 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 HCK HIST1H4F LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 PACSIN3 RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1	18 interactors: ADAM12 ADAM15 ASAP1 ASAP2 DNM1 ITSN1 LGALS13 PACSIN1 PACSIN2 PAK2 RAF1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TRPV4 WASL
Entrez ID		5062	29763
HPRD ID		05428	05937
Ensembl ID		ENSG00000180370	ENSG00000165912
Uniprot IDs		A8K5M4 Q13177	Q9UKS6
PDB IDs		3PCS
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Cytoskeleton Organization Chemotaxis Phagocytosis Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway Axon Development Cellular Response To Peptide Hormone Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Cellular Response To Peptide Cell Projection Organization Actin Filament-based Process Neuron Projection Morphogenesis Signal Transduction Signaling Response To Peptide Hormone Peptidyl-tyrosine Autophosphorylation Cell Communication Innate Immune Response Cellular Response To Organonitrogen Compound Cell Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Peptide Intracellular Signal Transduction Actin Cytoskeleton Organization Cell Projection Morphogenesis Regulation Of Immune System Process Cellular Response To Organic Substance Response To Growth Factor Cell Part Morphogenesis Programmed Cell Death	Cell Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Development Regulation Of Ras Protein Signal Transduction Anatomical Structure Development Cell Differentiation Generation Of Neurons Regulation Of Small GTPase Mediated Signal Transduction Neuron Differentiation Neurogenesis Developmental Process Regulation Of Ras GTPase Activity Synaptic Vesicle Endocytosis Cell Development Synaptic Vesicle Recycling Establishment Of Organelle Localization Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Endocytosis Organelle Localization Establishment Of Vesicle Localization Nervous System Development Regulation Of GTPase Activity Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Regulation Of Signaling Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway
Tagcloud ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Difference) ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Intersection) ?