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PAK2 and MYLK
Number of citations of the paper that reports this interaction (PubMedID
10748018
)
0
Data Source:
HPRD
(in vitro, in vivo)
PAK2
MYLK
Description
p21 (RAC1) activated kinase 2
myosin light chain kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Postsynaptic Density
Membrane
Nuclear Speck
Secretory Granule
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Stress Fiber
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Actin Cytoskeleton
Lamellipodium
Cleavage Furrow
Cell Projection
Synapse
Molecular Function
Nucleotide Binding
Catalytic Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Small GTPase Binding
Identical Protein Binding
Cadherin Binding
Protein Serine Kinase Activity
Nucleotide Binding
Actin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Myosin Light Chain Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Scaffold Protein Binding
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Cardiac Muscle Hypertrophy
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Starvation
Cell Migration
Adherens Junction Assembly
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Protein Maturation
Dendritic Spine Development
Bicellular Tight Junction Assembly
Cellular Response To Transforming Growth Factor Beta Stimulus
Execution Phase Of Apoptosis
Regulation Of Actin Filament Organization
Protein Localization To Cell-cell Junction
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein Phosphorylation
Smooth Muscle Contraction
Muscle Organ Development
Tonic Smooth Muscle Contraction
Positive Regulation Of Cell Migration
Bleb Assembly
Positive Regulation Of Calcium Ion Transport
Aorta Smooth Muscle Tissue Morphogenesis
Cellular Hypotonic Response
Positive Regulation Of Wound Healing
Regulation Of Synaptic Vesicle Endocytosis
Pathways
Nef and signal transduction
Generation of second messenger molecules
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Stimulation of the cell death response by PAK-2p34
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Smooth Muscle Contraction
RHO GTPases activate PAKs
RHO GTPases activate PAKs
Drugs
Fostamatinib
Ritodrine
Fostamatinib
Diseases
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Asthma (
31959851
)
Atrial fibrillation (
29892015
)
Eosinophil count (
32888494
27863252
)
Glucose homeostasis traits (
25524916
)
Lymphocyte count (
27863252
32888494
)
Malaria (
31844061
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
27863252
32888494
)
Neutrophil count (
32888494
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
White blood cell count (
27863252
32888494
)
General cognitive ability (
29844566
)
Interacting Genes
54 interacting genes:
ABI1
ABI2
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
CEBPA
DOCK2
DSCR9
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
H4C6
HCK
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NPHP1
OGT
PACSIN3
PPM1A
RAC1
RAF1
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
15 interacting genes:
ACTA1
ACTC1
APPBP2
CALM1
CAMK2G
CTTN
GOPC
HSPB1
MAPK3
MLC1
PAK1
PAK2
PRKCA
PRKG2
SRC
Entrez ID
5062
4638
HPRD ID
05428
02952
Ensembl ID
ENSG00000180370
ENSG00000065534
Uniprot IDs
A8K5M4
Q13177
A0A8I5KTQ1
A0A8I5KU53
Q05B97
Q05B98
Q15746
PDB IDs
3PCS
2CQV
2K0F
2YR3
5JQA
5JTH
6C6M
Enriched GO Terms of Interacting Partners
?
Regulation Of Cellular Component Organization
Cytosol
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intracellular Signal Transduction
Regulation Of Vesicle-mediated Transport
Cytoskeleton Organization
Positive Regulation Of Cellular Component Organization
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Cytoplasm
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Enzyme-linked Receptor Protein Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of MAPK Cascade
Focal Adhesion
Protein Phosphorylation
Ephrin Receptor Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Organelle Organization
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Fc Receptor Signaling Pathway
Phosphorylation
Positive Regulation Of Cytoskeleton Organization
Signal Transduction
Anchoring Junction
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Organelle Organization
Cell Surface Receptor Signaling Pathway
Regulation Of Protein-containing Complex Assembly
Immune Response-activating Signaling Pathway
Actin Cytoskeleton Organization
Non-membrane Spanning Protein Tyrosine Kinase Activity
Endocytosis
Regulation Of Cell Activation
Regulation Of Transport
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Regulation Of Supramolecular Fiber Organization
Regulation Of Endocytosis
Regulation Of T Cell Activation
Ephrin Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Supramolecular Fiber Organization
Actin Filament-based Process
Protein Kinase Activity
Lamellipodium
Actin Filament
Focal Adhesion
Protein Kinase Activity
ATP Binding
Cytoskeleton
Protein Serine Kinase Activity
Kinase Activity
Protein Serine/threonine Kinase Activity
Cellular Response To Lectin
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Muscle System Process
Nucleotide Binding
Intracellular Protein Localization
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of System Process
Mesenchyme Migration
Positive Regulation Of Locomotion
Caveolin-mediated Endocytosis
Protein Phosphorylation
Skeletal Muscle Thin Filament Assembly
Sarcomere
Cytosol
Phosphorylation
Lamellipodium
Regulation Of Transport
Cell-cell Junction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Caveola
Cytoplasm
Identical Protein Binding
Negative Regulation Of Apoptotic Process
Regulation Of Monoatomic Anion Transport
Regulation Of Cellular Localization
Cellular Response To Nutrient Levels
Negative Regulation Of Programmed Cell Death
Cell Junction Assembly
Regulation Of Protein Localization
Positive Regulation Of Cell Migration
Protein Tyrosine Kinase Activator Activity
Negative Regulation Of Monoatomic Ion Transport
Positive Regulation Of Cell Motility
Regulation Of Early Endosome To Late Endosome Transport
Response To Growth Factor
Protein Autophosphorylation
Enzyme-linked Receptor Protein Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Locomotion
Regulation Of MAPK Cascade
ERBB2 Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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