PAK2 and ARHGEF7

Number of citations of the paper that reports this interaction (PMID 12226077)
26

Data Source:
HPRD (in vitro, in vivo)

		PAK2	ARHGEF7
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 2	Rho guanine nucleotide exchange factor (GEF) 7
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Neuron Projection Neuronal Cell Body Protein Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Axon Guidance Viral Process Phosphorylation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Hematopoietic Progenitor Cell Differentiation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Regulation of PAK-2p34 activity by PS-GAP/RHG10 Costimulation by the CD28 family Axon guidance HIV Infection FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Nef and signal transduction Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability Programmed Cell Death EPH-Ephrin signaling Innate Immune System Generation of second messenger molecules Semaphorin interactions Apoptotic execution phase CD28 co-stimulation Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis CD28 dependent Vav1 pathway Stimulation of the cell death response by PAK-2p34 TCR signaling Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Regulation of Apoptosis Adaptive Immune System	EGFR downregulation Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Rho GTPase cycle Signaling by EGFR GPCR downstream signaling Ephrin signaling NRAGE signals death through JNK Signaling by Rho GTPases Signaling by EGFR in Cancer EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Total ventricular volume ( 21116278)	Bilirubin levels ( 19414484) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		51 interactors: ABI1 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 HCK HIST1H4F LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 PACSIN3 RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1	28 interactors: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 ERBB2IP GIT1 GIT2 LRRK2 MEOX2 NCK1 NCKIPSD PAK1 PAK2 PAK3 PPM1E PPM1F PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG
Entrez ID		5062	8874
HPRD ID		05428	05688
Ensembl ID		ENSG00000180370	ENSG00000102606
Uniprot IDs		A8K5M4 Q13177	B7Z6G2 E9PDQ5 Q14155
PDB IDs		3PCS	1BY1 1ZSG 2L3G
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Cytoskeleton Organization Chemotaxis Phagocytosis Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway Axon Development Cellular Response To Peptide Hormone Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Cellular Response To Peptide Cell Projection Organization Actin Filament-based Process Neuron Projection Morphogenesis Signal Transduction Signaling Response To Peptide Hormone Peptidyl-tyrosine Autophosphorylation Cell Communication Innate Immune Response Cellular Response To Organonitrogen Compound Cell Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Peptide Intracellular Signal Transduction Actin Cytoskeleton Organization Cell Projection Morphogenesis Regulation Of Immune System Process Cellular Response To Organic Substance Response To Growth Factor Cell Part Morphogenesis Programmed Cell Death	Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Signaling Cell Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cell Adhesion Regulation Of T Cell Activation Neuron Projection Morphogenesis Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Positive Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Development Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Positive Regulation Of T Cell Activation Neuron Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Actin Cytoskeleton Organization Nervous System Development Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Positive Regulation Of Transferase Activity Axon Guidance Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Development
Tagcloud ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Difference) ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
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